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000137629 0247_ $$2doi$$a10.1007/s00018-014-1677-1
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000137629 0247_ $$2ISSN$$a1420-682X
000137629 0247_ $$2ISSN$$a1420-9071
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000137629 037__ $$aDZNE-2020-03951
000137629 041__ $$aEnglish
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000137629 1001_ $$0P:(DE-2719)2289209$$aEhninger, Dan$$b0$$eFirst author$$udzne
000137629 245__ $$aLongevity, aging and rapamycin.
000137629 260__ $$aCham (ZG)$$bSpringer International Publishing AG$$c2014
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000137629 520__ $$aThe federal drug administration (FDA)-approved compound rapamycin was the first pharmacological agent shown to extend maximal lifespan in both genders in a mammalian species. A major question then is whether the drug slows mammalian aging or if it has isolated effects on longevity by suppressing cancers, the main cause of death in many mouse strains. Here, we review what is currently known about the effects that pharmacological or genetic mammalian target of rapamycin (mTOR) inhibition have on mammalian aging and longevity. Currently available evidence seems to best fit a model, wherein rapamycin extends lifespan by suppressing cancers. In addition the drug has symptomatic effects on some aging traits, such as age-related cognitive impairments.
000137629 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000137629 650_7 $$2NLM Chemicals$$aAntibiotics, Antineoplastic
000137629 650_7 $$0EC 2.7.1.1$$2NLM Chemicals$$aTOR Serine-Threonine Kinases
000137629 650_7 $$0W36ZG6FT64$$2NLM Chemicals$$aSirolimus
000137629 650_2 $$2MeSH$$aAging
000137629 650_2 $$2MeSH$$aAnimals
000137629 650_2 $$2MeSH$$aAntibiotics, Antineoplastic: pharmacology
000137629 650_2 $$2MeSH$$aGene Expression Regulation: drug effects
000137629 650_2 $$2MeSH$$aHumans
000137629 650_2 $$2MeSH$$aLongevity: drug effects
000137629 650_2 $$2MeSH$$aNeurons: drug effects
000137629 650_2 $$2MeSH$$aNeurons: metabolism
000137629 650_2 $$2MeSH$$aSignal Transduction: drug effects
000137629 650_2 $$2MeSH$$aSirolimus: pharmacology
000137629 650_2 $$2MeSH$$aTOR Serine-Threonine Kinases: metabolism
000137629 7001_ $$aNeff, Frauke$$b1
000137629 7001_ $$0P:(DE-2719)2810906$$aXie, Kan$$b2$$eLast author$$udzne
000137629 77318 $$2Crossref$$3journal-article$$a10.1007/s00018-014-1677-1$$b : Springer Science and Business Media LLC, 2014-07-12$$n22$$p4325-4346$$tCellular and Molecular Life Sciences$$v71$$x1420-682X$$y2014
000137629 773__ $$0PERI:(DE-600)1458497-9$$a10.1007/s00018-014-1677-1$$gVol. 71, no. 22, p. 4325 - 4346$$n22$$p4325-4346$$q71:22<4325 - 4346$$tCellular and molecular life sciences$$v71$$x1420-682X$$y2014
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