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@ARTICLE{Ehninger:137629,
      author       = {Ehninger, Dan and Neff, Frauke and Xie, Kan},
      title        = {{L}ongevity, aging and rapamycin.},
      journal      = {Cellular and molecular life sciences},
      volume       = {71},
      number       = {22},
      issn         = {1420-682X},
      address      = {Cham (ZG)},
      publisher    = {Springer International Publishing AG},
      reportid     = {DZNE-2020-03951},
      pages        = {4325-4346},
      year         = {2014},
      abstract     = {The federal drug administration (FDA)-approved compound
                      rapamycin was the first pharmacological agent shown to
                      extend maximal lifespan in both genders in a mammalian
                      species. A major question then is whether the drug slows
                      mammalian aging or if it has isolated effects on longevity
                      by suppressing cancers, the main cause of death in many
                      mouse strains. Here, we review what is currently known about
                      the effects that pharmacological or genetic mammalian target
                      of rapamycin (mTOR) inhibition have on mammalian aging and
                      longevity. Currently available evidence seems to best fit a
                      model, wherein rapamycin extends lifespan by suppressing
                      cancers. In addition the drug has symptomatic effects on
                      some aging traits, such as age-related cognitive
                      impairments.},
      subtyp        = {Review Article},
      keywords     = {Aging / Animals / Antibiotics, Antineoplastic: pharmacology
                      / Gene Expression Regulation: drug effects / Humans /
                      Longevity: drug effects / Neurons: drug effects / Neurons:
                      metabolism / Signal Transduction: drug effects / Sirolimus:
                      pharmacology / TOR Serine-Threonine Kinases: metabolism /
                      Antibiotics, Antineoplastic (NLM Chemicals) / TOR
                      Serine-Threonine Kinases (NLM Chemicals) / Sirolimus (NLM
                      Chemicals)},
      cin          = {AG Ehninger},
      ddc          = {610},
      cid          = {I:(DE-2719)1013005},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25015322},
      pmc          = {pmc:PMC4207939},
      doi          = {10.1007/s00018-014-1677-1},
      url          = {https://pub.dzne.de/record/137629},
}