Home > Publications Database > Longevity, aging and rapamycin. > print

001     137629
005     20250417100101.0
024 7 _ |a 10.1007/s00018-014-1677-1
|2 doi
024 7 _ |a pmid:25015322
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024 7 _ |a pmc:PMC4207939
|2 pmc
024 7 _ |a 0014-4754
|2 ISSN
024 7 _ |a 1420-682X
|2 ISSN
024 7 _ |a 1420-9071
|2 ISSN
024 7 _ |a altmetric:2579287
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037 _ _ |a DZNE-2020-03951
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Ehninger, Dan
|0 P:(DE-2719)2289209
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|e First author
|u dzne
245 _ _ |a Longevity, aging and rapamycin.
260 _ _ |a Cham (ZG)
|c 2014
|b Springer International Publishing AG
264 _ 1 |3 online
|2 Crossref
|b Springer Science and Business Media LLC
|c 2014-07-12
264 _ 1 |3 print
|2 Crossref
|b Springer Science and Business Media LLC
|c 2014-11-01
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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|s 1744795159_30974
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a The federal drug administration (FDA)-approved compound rapamycin was the first pharmacological agent shown to extend maximal lifespan in both genders in a mammalian species. A major question then is whether the drug slows mammalian aging or if it has isolated effects on longevity by suppressing cancers, the main cause of death in many mouse strains. Here, we review what is currently known about the effects that pharmacological or genetic mammalian target of rapamycin (mTOR) inhibition have on mammalian aging and longevity. Currently available evidence seems to best fit a model, wherein rapamycin extends lifespan by suppressing cancers. In addition the drug has symptomatic effects on some aging traits, such as age-related cognitive impairments.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
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542 _ _ |i 2014-07-12
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|u http://creativecommons.org/licenses/by/4.0
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Antibiotics, Antineoplastic
|2 NLM Chemicals
650 _ 7 |a TOR Serine-Threonine Kinases
|0 EC 2.7.1.1
|2 NLM Chemicals
650 _ 7 |a Sirolimus
|0 W36ZG6FT64
|2 NLM Chemicals
650 _ 2 |a Aging
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Antibiotics, Antineoplastic: pharmacology
|2 MeSH
650 _ 2 |a Gene Expression Regulation: drug effects
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Longevity: drug effects
|2 MeSH
650 _ 2 |a Neurons: drug effects
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Signal Transduction: drug effects
|2 MeSH
650 _ 2 |a Sirolimus: pharmacology
|2 MeSH
650 _ 2 |a TOR Serine-Threonine Kinases: metabolism
|2 MeSH
700 1 _ |a Neff, Frauke
|b 1
700 1 _ |a Xie, Kan
|0 P:(DE-2719)2810906
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773 1 8 |a 10.1007/s00018-014-1677-1
|b : Springer Science and Business Media LLC, 2014-07-12
|n 22
|p 4325-4346
|3 journal-article
|2 Crossref
|t Cellular and Molecular Life Sciences
|v 71
|y 2014
|x 1420-682X
773 _ _ |a 10.1007/s00018-014-1677-1
|g Vol. 71, no. 22, p. 4325 - 4346
|0 PERI:(DE-600)1458497-9
|n 22
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|p 4325-4346
|t Cellular and molecular life sciences
|v 71
|y 2014
|x 1420-682X
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/137629/files/DZNE-2020-03951.pdf
856 4 _ |y OpenAccess
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856 7 _ |2 Pubmed Central
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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914 1 _ |y 2014
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