TY  - JOUR
AU  - Huber, M.
AU  - Blumberg, A.
AU  - Chatterjee, S.
AU  - Hänisch, Britta
AU  - Schlosser-Weber, G.
AU  - Broich, K.
TI  - [Drug safety: challenge in an aging society].
JO  - Der Nervenarzt
VL  - 85
IS  - 11
SN  - 0028-2804
CY  - Heidelberg
PB  - Springer
M1  - DZNE-2020-03953
SP  - 1352-1362
PY  - 2014
AB  - Within the context of the demographic change the proportion of the elderly in the overall population is steadily increasing. At the same time elderly patients are prescribed a disproportionately high number of medicines in comparison to younger patients. In the light of multimorbidity and polypharmacy which affect a relevant portion of the older population, drug safety is of particular importance.In recent years, the prescription of psychiatric drugs to elderly patients was repeatedly subjected to regulatory assessment and recommendations, for example the safety of antipsychotics in patients with dementia. As only limited information is often available with respect to the risks of medicines in the elderly population, additional efforts are necessary for improvement of the database. In this context, the system of spontaneous reporting, e.g. the reporting of cases of suspected adverse drug reactions to the responsible authorities, plays an important role with respect to the additional knowledge to be gathered. By reporting observed adverse drug reactions as well as by the quality of the reported information, physicians are able to significantly influence the effectiveness of this system in a positive way.As medical care for the majority of the elderly population is provided by general practitioners, adequate longitudinal studies are of special interest for investigating drug safety in the elderly. This aim is being pursued by the AgeCoDe study (German study on aging, cognition and dementia in primary care patients), a prospective, multicentre observational study, which is being carried out within the German competence network of degenerative dementia (Kompetenznetz Degenerative Demenzen).
KW  - Adverse Drug Reaction Reporting Systems: organization & administration
KW  - Aged
KW  - Aged, 80 and over
KW  - Antipsychotic Agents: adverse effects
KW  - Drug Prescriptions: statistics & numerical data
KW  - Drug-Related Side Effects and Adverse Reactions: epidemiology
KW  - Drug-Related Side Effects and Adverse Reactions: etiology
KW  - Drug-Related Side Effects and Adverse Reactions: prevention & control
KW  - Female
KW  - Germany: epidemiology
KW  - Humans
KW  - Incidence
KW  - Male
KW  - Mandatory Reporting
KW  - Mental Disorders: drug therapy
KW  - Mental Disorders: epidemiology
KW  - Risk Assessment
KW  - Risk Factors
KW  - Antipsychotic Agents (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25294667
DO  - DOI:10.1007/s00115-014-4088-5
UR  - https://pub.dzne.de/record/137631
ER  -