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@ARTICLE{Huber:137631,
      author       = {Huber, M. and Blumberg, A. and Chatterjee, S. and Hänisch,
                      Britta and Schlosser-Weber, G. and Broich, K.},
      title        = {[{D}rug safety: challenge in an aging society].},
      journal      = {Der Nervenarzt},
      volume       = {85},
      number       = {11},
      issn         = {0028-2804},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DZNE-2020-03953},
      pages        = {1352-1362},
      year         = {2014},
      abstract     = {Within the context of the demographic change the proportion
                      of the elderly in the overall population is steadily
                      increasing. At the same time elderly patients are prescribed
                      a disproportionately high number of medicines in comparison
                      to younger patients. In the light of multimorbidity and
                      polypharmacy which affect a relevant portion of the older
                      population, drug safety is of particular importance.In
                      recent years, the prescription of psychiatric drugs to
                      elderly patients was repeatedly subjected to regulatory
                      assessment and recommendations, for example the safety of
                      antipsychotics in patients with dementia. As only limited
                      information is often available with respect to the risks of
                      medicines in the elderly population, additional efforts are
                      necessary for improvement of the database. In this context,
                      the system of spontaneous reporting, e.g. the reporting of
                      cases of suspected adverse drug reactions to the responsible
                      authorities, plays an important role with respect to the
                      additional knowledge to be gathered. By reporting observed
                      adverse drug reactions as well as by the quality of the
                      reported information, physicians are able to significantly
                      influence the effectiveness of this system in a positive
                      way.As medical care for the majority of the elderly
                      population is provided by general practitioners, adequate
                      longitudinal studies are of special interest for
                      investigating drug safety in the elderly. This aim is being
                      pursued by the AgeCoDe study (German study on aging,
                      cognition and dementia in primary care patients), a
                      prospective, multicentre observational study, which is being
                      carried out within the German competence network of
                      degenerative dementia (Kompetenznetz Degenerative
                      Demenzen).},
      keywords     = {Adverse Drug Reaction Reporting Systems: organization $\&$
                      administration / Aged / Aged, 80 and over / Antipsychotic
                      Agents: adverse effects / Drug Prescriptions: statistics
                      $\&$ numerical data / Drug-Related Side Effects and Adverse
                      Reactions: epidemiology / Drug-Related Side Effects and
                      Adverse Reactions: etiology / Drug-Related Side Effects and
                      Adverse Reactions: prevention $\&$ control / Female /
                      Germany: epidemiology / Humans / Incidence / Male /
                      Mandatory Reporting / Mental Disorders: drug therapy /
                      Mental Disorders: epidemiology / Risk Assessment / Risk
                      Factors / Antipsychotic Agents (NLM Chemicals)},
      cin          = {AG Hänisch},
      ddc          = {610},
      cid          = {I:(DE-2719)1013010},
      pnm          = {345 - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25294667},
      doi          = {10.1007/s00115-014-4088-5},
      url          = {https://pub.dzne.de/record/137631},
}