000137713 001__ 137713
000137713 005__ 20240321220311.0
000137713 0247_ $$2doi$$a10.1371/journal.pone.0113557
000137713 0247_ $$2pmid$$apmid:25437199
000137713 0247_ $$2pmc$$apmc:PMC4249965
000137713 0247_ $$2altmetric$$aaltmetric:2942377
000137713 037__ $$aDZNE-2020-04035
000137713 041__ $$aEnglish
000137713 082__ $$a610
000137713 1001_ $$0P:(DE-2719)2813308$$aHöllerhage, Matthias$$b0$$eFirst author$$udzne
000137713 245__ $$aPiericidin A aggravates Tau pathology in P301S transgenic mice.
000137713 260__ $$aSan Francisco, California, US$$bPLOS$$c2014
000137713 264_1 $$2Crossref$$3online$$bPublic Library of Science (PLoS)$$c2014-12-01
000137713 3367_ $$2DRIVER$$aarticle
000137713 3367_ $$2DataCite$$aOutput Types/Journal article
000137713 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1603707622_24016
000137713 3367_ $$2BibTeX$$aARTICLE
000137713 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000137713 3367_ $$00$$2EndNote$$aJournal Article
000137713 520__ $$aThe P301S mutation in exon 10 of the tau gene causes a hereditary tauopathy. While mitochondrial complex I inhibition has been linked to sporadic tauopathies. Piericidin A is a prototypical member of the group of the piericidins, a class of biologically active natural complex I inhibitors, isolated from streptomyces spp. with global distribution in marine and agricultural habitats. The aim of this study was to determine whether there is a pathogenic interaction of the environmental toxin piericidin A and the P301S mutation.Transgenic mice expressing human tau with the P301S-mutation (P301S+/+) and wild-type mice at 12 weeks of age were treated subcutaneously with vehicle (N = 10 P301S+/+, N = 7 wild-type) or piericidin A (N = 9 P301S+/+, N = 9 wild-type mice) at a dose of 0.5 mg/kg/d for a period of 28 days via osmotic minipumps. Tau pathology was measured by stereological counts of cells immunoreative with antibodies against phosphorylated tau (AD2, AT8, AT180, and AT100) and corresponding Western blot analysis.Piericidin A significantly increased the number of phospho-tau immunoreactive cells in the cerebral cortex in P301S+/+ mice, but only to a variable and mild extent in wild-type mice. Furthermore, piericidin A led to increased levels of pathologically phosphorylated tau only in P301S+/+ mice. While we observed no apparent cell loss in the frontal cortex, the synaptic density was reduced by piericidin A treatment in P301S+/+ mice.This study shows that exposure to piericidin A aggravates the course of genetically determined tau pathology, providing experimental support for the concept of gene-environment interaction in the etiology of tauopathies.
000137713 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
000137713 542__ $$2Crossref$$i2014-12-01$$uhttp://creativecommons.org/licenses/by/4.0/
000137713 588__ $$aDataset connected to CrossRef, PubMed,
000137713 650_7 $$2NLM Chemicals$$aPyridines
000137713 650_7 $$2NLM Chemicals$$atau Proteins
000137713 650_7 $$08VT513UJ9R$$2NLM Chemicals$$apiericidin A
000137713 650_2 $$2MeSH$$aAnimals
000137713 650_2 $$2MeSH$$aCerebral Cortex: drug effects
000137713 650_2 $$2MeSH$$aCerebral Cortex: pathology
000137713 650_2 $$2MeSH$$aExons: genetics
000137713 650_2 $$2MeSH$$aGene-Environment Interaction
000137713 650_2 $$2MeSH$$aHumans
000137713 650_2 $$2MeSH$$aMice
000137713 650_2 $$2MeSH$$aMice, Transgenic
000137713 650_2 $$2MeSH$$aMutation
000137713 650_2 $$2MeSH$$aPhosphorylation: drug effects
000137713 650_2 $$2MeSH$$aPyridines: toxicity
000137713 650_2 $$2MeSH$$aSynapses: drug effects
000137713 650_2 $$2MeSH$$aSynapses: pathology
000137713 650_2 $$2MeSH$$aTauopathies: genetics
000137713 650_2 $$2MeSH$$aTauopathies: metabolism
000137713 650_2 $$2MeSH$$aTauopathies: pathology
000137713 650_2 $$2MeSH$$atau Proteins: genetics
000137713 650_2 $$2MeSH$$atau Proteins: metabolism
000137713 7001_ $$aDeck, Roman$$b1
000137713 7001_ $$0P:(DE-2719)2813101$$aDe Andrade, Anderson$$b2$$udzne
000137713 7001_ $$0P:(DE-2719)2811600$$aRespondek, Gesine$$b3$$udzne
000137713 7001_ $$0P:(DE-2719)2810884$$aXu, Hong$$b4$$udzne
000137713 7001_ $$0P:(DE-2719)2810437$$aRösler, Thomas W$$b5$$udzne
000137713 7001_ $$aSalama, Mohamed$$b6
000137713 7001_ $$aCarlsson, Thomas$$b7
000137713 7001_ $$aYamada, Elizabeth S$$b8
000137713 7001_ $$aGad El Hak, Seham A$$b9
000137713 7001_ $$aGoedert, Michel$$b10
000137713 7001_ $$0P:(DE-HGF)0$$aOertel, Wolfgang H$$b11
000137713 7001_ $$0P:(DE-2719)2811373$$aHöglinger, Günter U$$b12$$eLast author$$udzne
000137713 77318 $$2Crossref$$3journal-article$$a10.1371/journal.pone.0113557$$b : Public Library of Science (PLoS), 2014-12-01$$n12$$pe113557$$tPLoS ONE$$v9$$x1932-6203$$y2014
000137713 773__ $$0PERI:(DE-600)2267670-3$$a10.1371/journal.pone.0113557$$gVol. 9, no. 12, p. e113557 -$$n12$$pe113557$$q9:12<e113557 -$$tPLOS ONE$$v9$$x1932-6203$$y2014
000137713 8564_ $$uhttps://pub.dzne.de/record/137713/files/journal.pone.0113557.PDF$$yOpenAccess
000137713 8564_ $$uhttps://pub.dzne.de/record/137713/files/journal.pone.0113557.gif?subformat=icon$$xicon$$yOpenAccess
000137713 8564_ $$uhttps://pub.dzne.de/record/137713/files/journal.pone.0113557.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
000137713 8564_ $$uhttps://pub.dzne.de/record/137713/files/journal.pone.0113557.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
000137713 8564_ $$uhttps://pub.dzne.de/record/137713/files/journal.pone.0113557.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
000137713 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249965
000137713 909CO $$ooai:pub.dzne.de:137713$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000137713 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2813308$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000137713 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2813101$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000137713 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811600$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000137713 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810884$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000137713 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810437$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000137713 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811373$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b12$$kDZNE
000137713 9131_ $$0G:(DE-HGF)POF3-344$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vClinical and Health Care Research$$x0
000137713 9141_ $$y2014
000137713 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000137713 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ
000137713 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000137713 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000137713 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000137713 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPLOS ONE : 2017
000137713 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000137713 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000137713 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000137713 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000137713 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000137713 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000137713 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000137713 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000137713 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000137713 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000137713 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000137713 9201_ $$0I:(DE-2719)1110002$$kAG Höglinger 1$$lTranslational Neurodegeneration$$x0
000137713 980__ $$ajournal
000137713 980__ $$aVDB
000137713 980__ $$aUNRESTRICTED
000137713 980__ $$aI:(DE-2719)1110002
000137713 9801_ $$aFullTexts
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0896-6273(89)90210-9$$o10.1016/0896-6273(89)90210-9
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/bi00158a027$$o10.1021/bi00158a027
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0165-0173(00)00019-9$$o10.1016/S0165-0173(00)00019-9
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S1474-4422(13)70090-5$$o10.1016/S1474-4422(13)70090-5
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0169-328X(86)90033-1$$o10.1016/0169-328X(86)90033-1
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.72.5.1858$$o10.1073/pnas.72.5.1858
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00018-007-7220-x$$o10.1007/s00018-007-7220-x
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s12031-011-9593-4$$o10.1007/s12031-011-9593-4
000137713 999C5 $$2Crossref$$oEM Mandelkow 2012$$y2012
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1097/00005072-199906000-00011$$o10.1097/00005072-199906000-00011
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/1531-8249(199911)46:5<708::AID-ANA5>3.0.CO;2-K$$o10.1002/1531-8249(199911)46:5<708::AID-ANA5>3.0.CO;2-K
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00702-007-0632-9$$o10.1007/s00702-007-0632-9
000137713 999C5 $$2Crossref$$oD Caparros-Lefebvre 1999$$y1999
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/mds.20553$$o10.1002/mds.20553
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/brain/awl347$$o10.1093/brain/awl347
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/978-3-7091-6551-5_2$$o10.1007/978-3-7091-6551-5_2
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0031-9422(95)00836-5$$o10.1016/0031-9422(95)00836-5
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/mds.20632$$o10.1002/mds.20632
000137713 999C5 $$2Crossref$$oP Champy 2004$$y2004
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.1644-07.2007$$o10.1523/JNEUROSCI.1644-07.2007
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ng.859$$o10.1038/ng.859
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.expneurol.2009.08.004$$o10.1016/j.expneurol.2009.08.004
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/bi00844a010$$o10.1021/bi00844a010
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/ja01087a050$$o10.1021/ja01087a050
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1574-6976.2006.00033.x$$o10.1111/j.1574-6976.2006.00033.x
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.22-21-09340.2002$$o10.1523/JNEUROSCI.22-21-09340.2002
000137713 999C5 $$2Crossref$$o
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neurobiolaging.2003.04.007$$o10.1016/j.neurobiolaging.2003.04.007
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1086/514612$$o10.1086/514612
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.diagmicrobio.2007.06.009$$o10.1016/j.diagmicrobio.2007.06.009
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1471-4159.2005.03493.x$$o10.1111/j.1471-4159.2005.03493.x
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00415-003-1074-4$$o10.1007/s00415-003-1074-4
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2007.01.010$$o10.1016/j.neuron.2007.01.010
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/jnen/60.5.403$$o10.1093/jnen/60.5.403
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1097/00005072-199904000-00006$$o10.1097/00005072-199904000-00006
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1159/000077158$$o10.1159/000077158
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.expneurol.2013.12.017$$o10.1016/j.expneurol.2013.12.017
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M901095200$$o10.1074/jbc.M901095200
000137713 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pone.0094251$$o10.1371/journal.pone.0094251