Home > Publications Database > Piericidin A aggravates Tau pathology in P301S transgenic mice. > print

001     137713
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024 7 _ |a 10.1371/journal.pone.0113557
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024 7 _ |a pmid:25437199
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024 7 _ |a pmc:PMC4249965
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037 _ _ |a DZNE-2020-04035
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Höllerhage, Matthias
|0 P:(DE-2719)2813308
|b 0
|e First author
|u dzne
245 _ _ |a Piericidin A aggravates Tau pathology in P301S transgenic mice.
260 _ _ |a San Francisco, California, US
|c 2014
|b PLOS
264 _ 1 |3 online
|2 Crossref
|b Public Library of Science (PLoS)
|c 2014-12-01
336 7 _ |a article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a The P301S mutation in exon 10 of the tau gene causes a hereditary tauopathy. While mitochondrial complex I inhibition has been linked to sporadic tauopathies. Piericidin A is a prototypical member of the group of the piericidins, a class of biologically active natural complex I inhibitors, isolated from streptomyces spp. with global distribution in marine and agricultural habitats. The aim of this study was to determine whether there is a pathogenic interaction of the environmental toxin piericidin A and the P301S mutation.Transgenic mice expressing human tau with the P301S-mutation (P301S+/+) and wild-type mice at 12 weeks of age were treated subcutaneously with vehicle (N = 10 P301S+/+, N = 7 wild-type) or piericidin A (N = 9 P301S+/+, N = 9 wild-type mice) at a dose of 0.5 mg/kg/d for a period of 28 days via osmotic minipumps. Tau pathology was measured by stereological counts of cells immunoreative with antibodies against phosphorylated tau (AD2, AT8, AT180, and AT100) and corresponding Western blot analysis.Piericidin A significantly increased the number of phospho-tau immunoreactive cells in the cerebral cortex in P301S+/+ mice, but only to a variable and mild extent in wild-type mice. Furthermore, piericidin A led to increased levels of pathologically phosphorylated tau only in P301S+/+ mice. While we observed no apparent cell loss in the frontal cortex, the synaptic density was reduced by piericidin A treatment in P301S+/+ mice.This study shows that exposure to piericidin A aggravates the course of genetically determined tau pathology, providing experimental support for the concept of gene-environment interaction in the etiology of tauopathies.
536 _ _ |a 344 - Clinical and Health Care Research (POF3-344)
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542 _ _ |i 2014-12-01
|2 Crossref
|u http://creativecommons.org/licenses/by/4.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Pyridines
|2 NLM Chemicals
650 _ 7 |a tau Proteins
|2 NLM Chemicals
650 _ 7 |a piericidin A
|0 8VT513UJ9R
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Cerebral Cortex: drug effects
|2 MeSH
650 _ 2 |a Cerebral Cortex: pathology
|2 MeSH
650 _ 2 |a Exons: genetics
|2 MeSH
650 _ 2 |a Gene-Environment Interaction
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Transgenic
|2 MeSH
650 _ 2 |a Mutation
|2 MeSH
650 _ 2 |a Phosphorylation: drug effects
|2 MeSH
650 _ 2 |a Pyridines: toxicity
|2 MeSH
650 _ 2 |a Synapses: drug effects
|2 MeSH
650 _ 2 |a Synapses: pathology
|2 MeSH
650 _ 2 |a Tauopathies: genetics
|2 MeSH
650 _ 2 |a Tauopathies: metabolism
|2 MeSH
650 _ 2 |a Tauopathies: pathology
|2 MeSH
650 _ 2 |a tau Proteins: genetics
|2 MeSH
650 _ 2 |a tau Proteins: metabolism
|2 MeSH
700 1 _ |a Deck, Roman
|b 1
700 1 _ |a De Andrade, Anderson
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700 1 _ |a Respondek, Gesine
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700 1 _ |a Xu, Hong
|0 P:(DE-2719)2810884
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700 1 _ |a Rösler, Thomas W
|0 P:(DE-2719)2810437
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700 1 _ |a Salama, Mohamed
|b 6
700 1 _ |a Carlsson, Thomas
|b 7
700 1 _ |a Yamada, Elizabeth S
|b 8
700 1 _ |a Gad El Hak, Seham A
|b 9
700 1 _ |a Goedert, Michel
|b 10
700 1 _ |a Oertel, Wolfgang H
|0 P:(DE-HGF)0
|b 11
700 1 _ |a Höglinger, Günter U
|0 P:(DE-2719)2811373
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773 1 8 |a 10.1371/journal.pone.0113557
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773 _ _ |a 10.1371/journal.pone.0113557
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