TY  - JOUR
AU  - Lutz, Sharon M
AU  - Hokanson, John E
AU  - Lange, Christoph
TI  - An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies.
JO  - Frontiers in genetics
VL  - 5
SN  - 1664-8021
CY  - Lausanne
PB  - Frontiers Media
M1  - DZNE-2020-04040
SP  - 188
PY  - 2014
AB  - Motivated by the challenges associated with accounting for the ascertainment when analyzing secondary phenotypes that are correlated with case-control status, Lin and Zeng have proposed a method that properly reflects the case-control sampling (Lin and Zeng, 2009). The Lin and Zeng method has the advantage of accurately estimating effect sizes for secondary phenotypes that are normally distributed or dichotomous. This method can be computationally intensive in practice under the null hypothesis when the likelihood surface that needs to be maximized can be relatively flat. We propose an extension of the Lin and Zeng method for hypothesis testing that uses proportional odds logistic regression to circumvent these computational issues. Through simulation studies, we compare the power and type-1 error rate of our method to standard approaches and Lin and Zeng's approach.
LB  - PUB:(DE-HGF)16
C6  - pmid:25071819
C2  - pmc:PMC4076613
DO  - DOI:10.3389/fgene.2014.00188
UR  - https://pub.dzne.de/record/137718
ER  -