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000137726 037__ $$aDZNE-2020-04048
000137726 041__ $$aEnglish
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000137726 1001_ $$0P:(DE-HGF)0$$aMüller, Janine$$b0
000137726 245__ $$aIntrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in parkinsonian rats.
000137726 260__ $$aDurham$$bAlphaMed Press$$c2015
000137726 264_1 $$2Crossref$$3online$$bWiley$$c2014-12-05
000137726 264_1 $$2Crossref$$3print$$bWiley$$c2015-01-01
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000137726 520__ $$aParkinson's disease (PD) is considered the second most frequent and one of the most severe neurodegenerative diseases, with dysfunctions of the motor system and with nonmotor symptoms such as depression and dementia. Compensation for the progressive loss of dopaminergic (DA) neurons during PD using current pharmacological treatment strategies is limited and remains challenging. Pluripotent stem cell-based regenerative medicine may offer a promising therapeutic alternative, although the medical application of human embryonic tissue and pluripotent stem cells is still a matter of ethical and practical debate. Addressing these challenges, the present study investigated the potential of adult human neural crest-derived stem cells derived from the inferior turbinate (ITSCs) transplanted into a parkinsonian rat model. Emphasizing their capability to give rise to nervous tissue, ITSCs isolated from the adult human nose efficiently differentiated into functional mature neurons in vitro. Additional successful dopaminergic differentiation of ITSCs was subsequently followed by their transplantation into a unilaterally lesioned 6-hydroxydopamine rat PD model. Transplantation of predifferentiated or undifferentiated ITSCs led to robust restoration of rotational behavior, accompanied by significant recovery of DA neurons within the substantia nigra. ITSCs were further shown to migrate extensively in loose streams primarily toward the posterior direction as far as to the midbrain region, at which point they were able to differentiate into DA neurons within the locus ceruleus. We demonstrate, for the first time, that adult human ITSCs are capable of functionally recovering a PD rat model.
000137726 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
000137726 542__ $$2Crossref$$i2015-09-01$$uhttp://doi.wiley.com/10.1002/tdm_license_1.1
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000137726 650_2 $$2MeSH$$aAdult Stem Cells: cytology
000137726 650_2 $$2MeSH$$aAdult Stem Cells: transplantation
000137726 650_2 $$2MeSH$$aAnimals
000137726 650_2 $$2MeSH$$aCell Differentiation
000137726 650_2 $$2MeSH$$aFemale
000137726 650_2 $$2MeSH$$aHeterografts
000137726 650_2 $$2MeSH$$aHumans
000137726 650_2 $$2MeSH$$aImmunohistochemistry
000137726 650_2 $$2MeSH$$aNeural Crest: cytology
000137726 650_2 $$2MeSH$$aNeural Crest: transplantation
000137726 650_2 $$2MeSH$$aNeural Stem Cells: cytology
000137726 650_2 $$2MeSH$$aNeural Stem Cells: transplantation
000137726 650_2 $$2MeSH$$aParkinsonian Disorders: surgery
000137726 650_2 $$2MeSH$$aRats
000137726 650_2 $$2MeSH$$aRats, Wistar
000137726 650_2 $$2MeSH$$aRecovery of Function
000137726 650_2 $$2MeSH$$aReverse Transcriptase Polymerase Chain Reaction
000137726 650_2 $$2MeSH$$aStem Cell Transplantation: methods
000137726 7001_ $$0P:(DE-2719)2811159$$aOssig, Christiana$$b1$$udzne
000137726 7001_ $$0P:(DE-HGF)0$$aGreiner, Johannes F W$$b2
000137726 7001_ $$0P:(DE-HGF)0$$aHauser, Stefan$$b3
000137726 7001_ $$0P:(DE-2719)9000068$$aFauser, Mareike$$b4$$udzne
000137726 7001_ $$0P:(DE-HGF)0$$aWidera, Darius$$b5
000137726 7001_ $$0P:(DE-HGF)0$$aKaltschmidt, Christian$$b6
000137726 7001_ $$0P:(DE-2719)9000306$$aStorch, Alexander$$b7$$udzne
000137726 7001_ $$0P:(DE-HGF)0$$aKaltschmidt, Barbara$$b8$$eCorresponding author
000137726 77318 $$2Crossref$$3journal-article$$a10.5966/sctm.2014-0078$$b : Wiley, 2014-12-05$$n1$$p31-43$$tSTEM CELLS Translational Medicine$$v4$$x2157-6564$$y2014
000137726 773__ $$0PERI:(DE-600)2642270-0$$a10.5966/sctm.2014-0078$$gVol. 4, no. 1, p. 31 - 43$$n1$$p31-43$$q4:1<31 - 43$$tStem cells translational medicine$$v4$$x2157-6564$$y2015
000137726 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275008
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