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@ARTICLE{Mller:137726,
      author       = {Müller, Janine and Ossig, Christiana and Greiner, Johannes
                      F W and Hauser, Stefan and Fauser, Mareike and Widera,
                      Darius and Kaltschmidt, Christian and Storch, Alexander and
                      Kaltschmidt, Barbara},
      title        = {{I}ntrastriatal transplantation of adult human neural
                      crest-derived stem cells improves functional outcome in
                      parkinsonian rats.},
      journal      = {Stem cells translational medicine},
      volume       = {4},
      number       = {1},
      issn         = {2157-6564},
      address      = {Durham},
      publisher    = {AlphaMed Press},
      reportid     = {DZNE-2020-04048},
      pages        = {31-43},
      year         = {2015},
      abstract     = {Parkinson's disease (PD) is considered the second most
                      frequent and one of the most severe neurodegenerative
                      diseases, with dysfunctions of the motor system and with
                      nonmotor symptoms such as depression and dementia.
                      Compensation for the progressive loss of dopaminergic (DA)
                      neurons during PD using current pharmacological treatment
                      strategies is limited and remains challenging. Pluripotent
                      stem cell-based regenerative medicine may offer a promising
                      therapeutic alternative, although the medical application of
                      human embryonic tissue and pluripotent stem cells is still a
                      matter of ethical and practical debate. Addressing these
                      challenges, the present study investigated the potential of
                      adult human neural crest-derived stem cells derived from the
                      inferior turbinate (ITSCs) transplanted into a parkinsonian
                      rat model. Emphasizing their capability to give rise to
                      nervous tissue, ITSCs isolated from the adult human nose
                      efficiently differentiated into functional mature neurons in
                      vitro. Additional successful dopaminergic differentiation of
                      ITSCs was subsequently followed by their transplantation
                      into a unilaterally lesioned 6-hydroxydopamine rat PD model.
                      Transplantation of predifferentiated or undifferentiated
                      ITSCs led to robust restoration of rotational behavior,
                      accompanied by significant recovery of DA neurons within the
                      substantia nigra. ITSCs were further shown to migrate
                      extensively in loose streams primarily toward the posterior
                      direction as far as to the midbrain region, at which point
                      they were able to differentiate into DA neurons within the
                      locus ceruleus. We demonstrate, for the first time, that
                      adult human ITSCs are capable of functionally recovering a
                      PD rat model.},
      keywords     = {Adult Stem Cells: cytology / Adult Stem Cells:
                      transplantation / Animals / Cell Differentiation / Female /
                      Heterografts / Humans / Immunohistochemistry / Neural Crest:
                      cytology / Neural Crest: transplantation / Neural Stem
                      Cells: cytology / Neural Stem Cells: transplantation /
                      Parkinsonian Disorders: surgery / Rats / Rats, Wistar /
                      Recovery of Function / Reverse Transcriptase Polymerase
                      Chain Reaction / Stem Cell Transplantation: methods},
      cin          = {AG Storch / AG Kühn},
      ddc          = {610},
      cid          = {I:(DE-2719)5000014 / I:(DE-2719)5000008},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25479965},
      pmc          = {pmc:PMC4275008},
      doi          = {10.5966/sctm.2014-0078},
      url          = {https://pub.dzne.de/record/137726},
}