Home > Publications Database > Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in parkinsonian rats. > print

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024 7 _ |a 10.5966/sctm.2014-0078
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024 7 _ |a pmid:25479965
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024 7 _ |a pmc:PMC4275008
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024 7 _ |a 2157-6564
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024 7 _ |a 2157-6580
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037 _ _ |a DZNE-2020-04048
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Müller, Janine
|0 P:(DE-HGF)0
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245 _ _ |a Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in parkinsonian rats.
260 _ _ |a Durham
|c 2015
|b AlphaMed Press
264 _ 1 |3 online
|2 Crossref
|b Wiley
|c 2014-12-05
264 _ 1 |3 print
|2 Crossref
|b Wiley
|c 2015-01-01
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Parkinson's disease (PD) is considered the second most frequent and one of the most severe neurodegenerative diseases, with dysfunctions of the motor system and with nonmotor symptoms such as depression and dementia. Compensation for the progressive loss of dopaminergic (DA) neurons during PD using current pharmacological treatment strategies is limited and remains challenging. Pluripotent stem cell-based regenerative medicine may offer a promising therapeutic alternative, although the medical application of human embryonic tissue and pluripotent stem cells is still a matter of ethical and practical debate. Addressing these challenges, the present study investigated the potential of adult human neural crest-derived stem cells derived from the inferior turbinate (ITSCs) transplanted into a parkinsonian rat model. Emphasizing their capability to give rise to nervous tissue, ITSCs isolated from the adult human nose efficiently differentiated into functional mature neurons in vitro. Additional successful dopaminergic differentiation of ITSCs was subsequently followed by their transplantation into a unilaterally lesioned 6-hydroxydopamine rat PD model. Transplantation of predifferentiated or undifferentiated ITSCs led to robust restoration of rotational behavior, accompanied by significant recovery of DA neurons within the substantia nigra. ITSCs were further shown to migrate extensively in loose streams primarily toward the posterior direction as far as to the midbrain region, at which point they were able to differentiate into DA neurons within the locus ceruleus. We demonstrate, for the first time, that adult human ITSCs are capable of functionally recovering a PD rat model.
536 _ _ |a 344 - Clinical and Health Care Research (POF3-344)
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|f POF III
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542 _ _ |i 2015-09-01
|2 Crossref
|u http://doi.wiley.com/10.1002/tdm_license_1.1
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 2 |a Adult Stem Cells: cytology
|2 MeSH
650 _ 2 |a Adult Stem Cells: transplantation
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Cell Differentiation
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Heterografts
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Immunohistochemistry
|2 MeSH
650 _ 2 |a Neural Crest: cytology
|2 MeSH
650 _ 2 |a Neural Crest: transplantation
|2 MeSH
650 _ 2 |a Neural Stem Cells: cytology
|2 MeSH
650 _ 2 |a Neural Stem Cells: transplantation
|2 MeSH
650 _ 2 |a Parkinsonian Disorders: surgery
|2 MeSH
650 _ 2 |a Rats
|2 MeSH
650 _ 2 |a Rats, Wistar
|2 MeSH
650 _ 2 |a Recovery of Function
|2 MeSH
650 _ 2 |a Reverse Transcriptase Polymerase Chain Reaction
|2 MeSH
650 _ 2 |a Stem Cell Transplantation: methods
|2 MeSH
700 1 _ |a Ossig, Christiana
|0 P:(DE-2719)2811159
|b 1
|u dzne
700 1 _ |a Greiner, Johannes F W
|0 P:(DE-HGF)0
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700 1 _ |a Hauser, Stefan
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700 1 _ |a Fauser, Mareike
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700 1 _ |a Widera, Darius
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700 1 _ |a Kaltschmidt, Christian
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700 1 _ |a Storch, Alexander
|0 P:(DE-2719)9000306
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700 1 _ |a Kaltschmidt, Barbara
|0 P:(DE-HGF)0
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|e Corresponding author
773 1 8 |a 10.5966/sctm.2014-0078
|b : Wiley, 2014-12-05
|n 1
|p 31-43
|3 journal-article
|2 Crossref
|t STEM CELLS Translational Medicine
|v 4
|y 2014
|x 2157-6564
773 _ _ |a 10.5966/sctm.2014-0078
|g Vol. 4, no. 1, p. 31 - 43
|0 PERI:(DE-600)2642270-0
|n 1
|q 4:1<31 - 43
|p 31-43
|t Stem cells translational medicine
|v 4
|y 2015
|x 2157-6564
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275008
856 4 _ |u https://pub.dzne.de/record/137726/files/DZNE-2020-04048_Restricted.pdf
856 4 _ |u https://pub.dzne.de/record/137726/files/DZNE-2020-04048_Restricted.pdf?subformat=pdfa
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909 C O |p VDB
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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|l Erkrankungen des Nervensystems
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914 1 _ |y 2015
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