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@ARTICLE{Toyoda:137741,
      author       = {Toyoda, Yusuke and Erkut, Cihan and Pan-Montojo, Francisco
                      and Boland, Sebastian and Stewart, Martin P and Müller,
                      Daniel J and Wurst, Wolfgang and Hyman, Anthony A and
                      Kurzchalia, Teymuras V},
      title        = {{P}roducts of the {P}arkinson's disease-related glyoxalase
                      {DJ}-1, {D}-lactate and glycolate, support mitochondrial
                      membrane potential and neuronal survival.},
      journal      = {Biology open},
      volume       = {3},
      number       = {8},
      issn         = {2046-6390},
      address      = {Cambridge},
      publisher    = {Company},
      reportid     = {DZNE-2020-04063},
      pages        = {777-784},
      year         = {2014},
      abstract     = {Parkinson's disease is associated with mitochondrial
                      decline in dopaminergic neurons of the substantia nigra. One
                      of the genes linked with the onset of Parkinson's disease,
                      DJ-1/PARK7, belongs to a novel glyoxalase family and
                      influences mitochondrial activity. It has been assumed that
                      glyoxalases fulfill this task by detoxifying aggressive
                      aldehyde by-products of metabolism. Here we show that
                      supplying either D-lactate or glycolate, products of DJ-1,
                      rescues the requirement for the enzyme in maintenance of
                      mitochondrial potential. We further show that glycolic acid
                      and D-lactic acid can elevate lowered mitochondrial membrane
                      potential caused by silencing PINK-1, another Parkinson's
                      related gene, as well as by paraquat, an environmental toxin
                      known to be linked with Parkinson's disease. We propose that
                      DJ-1 and consequently its products are components of a novel
                      pathway that stabilizes mitochondria during cellular stress.
                      We go on to show that survival of cultured mesencephalic
                      dopaminergic neurons, defective in Parkinson's disease, is
                      enhanced by glycolate and D-lactate. Because glycolic and
                      D-lactic acids occur naturally, they are therefore a
                      potential therapeutic route for treatment or prevention of
                      Parkinson's disease.},
      cin          = {AG Wurst},
      ddc          = {570},
      cid          = {I:(DE-2719)1140001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25063200},
      pmc          = {pmc:PMC4133730},
      doi          = {10.1242/bio.20149399},
      url          = {https://pub.dzne.de/record/137741},
}