Home > Publications Database > Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival. > print

001     137741
005     20240604120452.0
024 7 _ |a 10.1242/bio.20149399
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037 _ _ |a DZNE-2020-04063
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Toyoda, Yusuke
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245 _ _ |a Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival.
260 _ _ |a Cambridge
|c 2014
|b Company
264 _ 1 |3 online
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|b The Company of Biologists
|c 2014-07-25
264 _ 1 |3 print
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|b The Company of Biologists
|c 2014-08-15
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336 7 _ |a ARTICLE
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520 _ _ |a Parkinson's disease is associated with mitochondrial decline in dopaminergic neurons of the substantia nigra. One of the genes linked with the onset of Parkinson's disease, DJ-1/PARK7, belongs to a novel glyoxalase family and influences mitochondrial activity. It has been assumed that glyoxalases fulfill this task by detoxifying aggressive aldehyde by-products of metabolism. Here we show that supplying either D-lactate or glycolate, products of DJ-1, rescues the requirement for the enzyme in maintenance of mitochondrial potential. We further show that glycolic acid and D-lactic acid can elevate lowered mitochondrial membrane potential caused by silencing PINK-1, another Parkinson's related gene, as well as by paraquat, an environmental toxin known to be linked with Parkinson's disease. We propose that DJ-1 and consequently its products are components of a novel pathway that stabilizes mitochondria during cellular stress. We go on to show that survival of cultured mesencephalic dopaminergic neurons, defective in Parkinson's disease, is enhanced by glycolate and D-lactate. Because glycolic and D-lactic acids occur naturally, they are therefore a potential therapeutic route for treatment or prevention of Parkinson's disease.
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700 1 _ |a Erkut, Cihan
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700 1 _ |a Pan-Montojo, Francisco
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700 1 _ |a Boland, Sebastian
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700 1 _ |a Stewart, Martin P
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700 1 _ |a Müller, Daniel J
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700 1 _ |a Wurst, Wolfgang
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700 1 _ |a Hyman, Anthony A
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700 1 _ |a Kurzchalia, Teymuras V
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773 1 8 |a 10.1242/bio.20149399
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773 _ _ |a 10.1242/bio.20149399
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856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/137741/files/DZNE-2020-04063.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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