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@ARTICLE{Vieweg:137830,
      author       = {Vieweg, Paula and Stangl, Matthias and Howard, Lorelei R
                      and Wolbers, Thomas},
      title        = {{C}hanges in pattern completion--a key mechanism to explain
                      age-related recognition memory deficits?},
      journal      = {Cortex},
      volume       = {64},
      issn         = {0010-9452},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-04152},
      pages        = {343-351},
      year         = {2015},
      abstract     = {Accurate memory retrieval from partial or degraded input
                      requires the reactivation of memory traces, a hippocampal
                      mechanism termed pattern completion. Age-related changes in
                      hippocampal integrity have been hypothesized to shift the
                      balance of memory processes in favor of the retrieval of
                      already stored information (pattern completion), to the
                      detriment of encoding new events (pattern separation). Using
                      a novel behavioral paradigm, we investigated the impact of
                      cognitive aging (1) on recognition performance across
                      different levels of stimulus completeness, and (2) on
                      potential response biases. Participants were required to
                      identify previously learned scenes among new ones.
                      Additionally, all stimuli were presented in gradually masked
                      versions to alter stimulus completeness. Both young and
                      older adults performed increasingly poorly as the scenes
                      became less complete, and this decline in performance was
                      more pronounced in elderly participants indicative of a
                      pattern completion deficit. Intriguingly, when novel scenes
                      were shown, only the older adults showed an increased
                      tendency to identify these as familiar scenes. In line with
                      theoretical models, we argue that this reflects an
                      age-related bias towards pattern completion.},
      keywords     = {Adult / Aged / Aging: physiology / Attention: physiology /
                      Female / Humans / Male / Memory: physiology / Memory
                      Disorders: physiopathology / Mental Recall: physiology /
                      Middle Aged / Neuropsychological Tests / Photic Stimulation
                      / Reaction Time: physiology / Young Adult},
      cin          = {AG Wolbers},
      ddc          = {610},
      cid          = {I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25597525},
      pmc          = {pmc:PMC4884644},
      doi          = {10.1016/j.cortex.2014.12.007},
      url          = {https://pub.dzne.de/record/137830},
}