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000137838 1001_ $$0P:(DE-2719)2810305$$aLacour, Andre$$b0$$eFirst author$$udzne
000137838 245__ $$aNovel genetic matching methods for handling population stratification in genome-wide association studies.
000137838 260__ $$aHeidelberg$$bSpringer$$c2015
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000137838 520__ $$aA usually confronted problem in association studies is the occurrence of population stratification. In this work, we propose a novel framework to consider population matchings in the contexts of genome-wide and sequencing association studies. We employ pairwise and groupwise optimal case-control matchings and present an agglomerative hierarchical clustering, both based on a genetic similarity score matrix. In order to ensure that the resulting matches obtained from the matching algorithm capture correctly the population structure, we propose and discuss two stratum validation methods. We also invent a decisive extension to the Cochran-Armitage Trend test to explicitly take into account the particular population structure.We assess our framework by simulations of genotype data under the null hypothesis, to affirm that it correctly controls for the type-1 error rate. By a power study we evaluate that structured association testing using our framework displays reasonable power. We compare our result with those obtained from a logistic regression model with principal component covariates. Using the principal components approaches we also find a possible false-positive association to Alzheimer's disease, which is neither supported by our new methods, nor by the results of a most recent large meta analysis or by a mixed model approach.Matching methods provide an alternative handling of confounding due to population stratification for statistical tests for which covariates are hard to model. As a benchmark, we show that our matching framework performs equally well to state of the art models on common variants.
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000137838 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000137838 650_2 $$2MeSH$$aCase-Control Studies
000137838 650_2 $$2MeSH$$aCluster Analysis
000137838 650_2 $$2MeSH$$aGenetics, Population
000137838 650_2 $$2MeSH$$aGenome-Wide Association Study: methods
000137838 650_2 $$2MeSH$$aGenotype
000137838 650_2 $$2MeSH$$aHumans
000137838 650_2 $$2MeSH$$aLogistic Models
000137838 650_2 $$2MeSH$$aPopulation Groups
000137838 7001_ $$0P:(DE-2719)2810897$$aSchüller, Vitalia$$b1$$udzne
000137838 7001_ $$0P:(DE-2719)2740473$$aDrichel, Dmitriy$$b2$$udzne
000137838 7001_ $$0P:(DE-2719)2802016$$aHerold, Christine$$b3$$udzne
000137838 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b4$$udzne
000137838 7001_ $$0P:(DE-HGF)0$$aLeber, Markus$$b5
000137838 7001_ $$0P:(DE-HGF)0$$aMaier, Wolfgang$$b6
000137838 7001_ $$0P:(DE-HGF)0$$aNoethen, Markus M$$b7
000137838 7001_ $$0P:(DE-HGF)0$$aRamirez, Alfredo$$b8
000137838 7001_ $$0P:(DE-HGF)0$$aVaitsiakhovich, Tatsiana$$b9
000137838 7001_ $$0P:(DE-2719)2501867$$aBecker, Tim$$b10$$eLast author$$udzne
000137838 77318 $$2Crossref$$3journal-article$$a10.1186/s12859-015-0521-4$$b : Springer Science and Business Media LLC, 2015-03-14$$n1$$p84$$tBMC Bioinformatics$$v16$$x1471-2105$$y2015
000137838 773__ $$0PERI:(DE-600)2041484-5$$a10.1186/s12859-015-0521-4$$gVol. 16, no. 1, p. 84$$n1$$p84$$q16:1<84$$tBMC bioinformatics$$v16$$x1471-2105$$y2015
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000137838 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ajhg.2014.06.009$$o10.1016/j.ajhg.2014.06.009
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000137838 999C5 $$2Crossref$$oWS Torgerson Theory & methods of scaling 1958$$tTheory & methods of scaling$$y1958
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