%0 Journal Article
%A Wolfsgruber, Steffen
%A Jessen, Frank
%A Koppara, Alexander
%A Kleineidam, Luca
%A Schmidtke, Klaus
%A Frölich, Lutz
%A Kurz, Alexander
%A Schulz, Stefanie
%A Hampel, Harald
%A Heuser, Isabella
%A Peters, Oliver
%A Reischies, Friedel M
%A Jahn, Holger
%A Luckhaus, Christian
%A Hüll, Michael
%A Gertz, Hermann-Josef
%A Schröder, Johannes
%A Pantel, Johannes
%A Rienhoff, Otto
%A Rüther, Eckart
%A Henn, Fritz
%A Wiltfang, Jens
%A Maier, Wolfgang
%A Kornhuber, Johannes
%A Wagner, Michael
%T Subjective cognitive decline is related to CSF biomarkers of AD in patients with MCI.
%J Neurology
%V 84
%N 12
%@ 0028-3878
%C [S.l.]
%I Ovid
%M DZNE-2020-04166
%P 1261-1268
%D 2015
%X To test whether, in individuals with mild cognitive impairment (MCI), different measures of subjective cognitive decline (SCD) in the memory domain predict abnormal CSF biomarkers of Alzheimer disease (AD).We analyzed the multicenter baseline (cross-sectional) data of 245 patients with MCI. SCD was measured quantitatively with the Subjective Memory Decline Scale (SMDS) and qualitatively by assessing particular concerns associated with self-experienced worsening of memory. Logistic regression models were used to examine associations between SCD and abnormal CSF biomarkers, taking into account objective memory impairment, depressive symptoms, and education as covariates.Abnormal CSF β-amyloid 1-42 (Aβ42) and more depressive symptoms were associated with higher SMDS scores and with the report of memory concerns. Risk of abnormal CSF Aβ42 increased by an estimated 57
%K Aged
%K Aged, 80 and over
%K Alzheimer Disease: cerebrospinal fluid
%K Alzheimer Disease: physiopathology
%K Alzheimer Disease: psychology
%K Amyloid beta-Peptides: cerebrospinal fluid
%K Biomarkers: cerebrospinal fluid
%K Cognitive Dysfunction: cerebrospinal fluid
%K Cognitive Dysfunction: physiopathology
%K Cognitive Dysfunction: psychology
%K Female
%K Humans
%K Male
%K Memory Disorders: cerebrospinal fluid
%K Memory Disorders: physiopathology
%K Memory Disorders: psychology
%K Middle Aged
%K Peptide Fragments: cerebrospinal fluid
%K Prodromal Symptoms
%K tau Proteins: cerebrospinal fluid
%K Amyloid beta-Peptides (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K Peptide Fragments (NLM Chemicals)
%K amyloid beta-protein (1-42) (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25716354
%R 10.1212/WNL.0000000000001399
%U https://pub.dzne.de/record/137844