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000137844 041__ $$aEnglish
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000137844 1001_ $$0P:(DE-2719)2810544$$aWolfsgruber, Steffen$$b0$$eFirst author$$udzne
000137844 245__ $$aSubjective cognitive decline is related to CSF biomarkers of AD in patients with MCI.
000137844 260__ $$a[S.l.]$$bOvid$$c2015
000137844 264_1 $$2Crossref$$3online$$bOvid Technologies (Wolters Kluwer Health)$$c2015-02-25
000137844 264_1 $$2Crossref$$3print$$bOvid Technologies (Wolters Kluwer Health)$$c2015-03-24
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000137844 520__ $$aTo test whether, in individuals with mild cognitive impairment (MCI), different measures of subjective cognitive decline (SCD) in the memory domain predict abnormal CSF biomarkers of Alzheimer disease (AD).We analyzed the multicenter baseline (cross-sectional) data of 245 patients with MCI. SCD was measured quantitatively with the Subjective Memory Decline Scale (SMDS) and qualitatively by assessing particular concerns associated with self-experienced worsening of memory. Logistic regression models were used to examine associations between SCD and abnormal CSF biomarkers, taking into account objective memory impairment, depressive symptoms, and education as covariates.Abnormal CSF β-amyloid 1-42 (Aβ42) and more depressive symptoms were associated with higher SMDS scores and with the report of memory concerns. Risk of abnormal CSF Aβ42 increased by an estimated 57% for a 1-SD increase in SMDS scores and was doubled in patients who had SMDS scores >4 or who reported memory concerns, respectively. In addition, both SCD measures predicted risk of having a biomarker signature indicative of prodromal AD defined as presence of low CSF Aβ42 together with either high CSF tau or CSF phosphorylated tau 181 levels.In MCI, specific aspects of SCD severity and quality are related to CSF biomarkers indicative of AD. This extends findings in pre-MCI samples and calls for an improved operational assessment of SCD in MCI. This might be useful for sample enrichment strategies for increased likelihood of AD pathology.
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000137844 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000137844 650_7 $$2NLM Chemicals$$aBiomarkers
000137844 650_7 $$2NLM Chemicals$$aPeptide Fragments
000137844 650_7 $$2NLM Chemicals$$aamyloid beta-protein (1-42)
000137844 650_7 $$2NLM Chemicals$$atau Proteins
000137844 650_2 $$2MeSH$$aAged
000137844 650_2 $$2MeSH$$aAged, 80 and over
000137844 650_2 $$2MeSH$$aAlzheimer Disease: cerebrospinal fluid
000137844 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000137844 650_2 $$2MeSH$$aAlzheimer Disease: psychology
000137844 650_2 $$2MeSH$$aAmyloid beta-Peptides: cerebrospinal fluid
000137844 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000137844 650_2 $$2MeSH$$aCognitive Dysfunction: cerebrospinal fluid
000137844 650_2 $$2MeSH$$aCognitive Dysfunction: physiopathology
000137844 650_2 $$2MeSH$$aCognitive Dysfunction: psychology
000137844 650_2 $$2MeSH$$aFemale
000137844 650_2 $$2MeSH$$aHumans
000137844 650_2 $$2MeSH$$aMale
000137844 650_2 $$2MeSH$$aMemory Disorders: cerebrospinal fluid
000137844 650_2 $$2MeSH$$aMemory Disorders: physiopathology
000137844 650_2 $$2MeSH$$aMemory Disorders: psychology
000137844 650_2 $$2MeSH$$aMiddle Aged
000137844 650_2 $$2MeSH$$aPeptide Fragments: cerebrospinal fluid
000137844 650_2 $$2MeSH$$aProdromal Symptoms
000137844 650_2 $$2MeSH$$atau Proteins: cerebrospinal fluid
000137844 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b1$$udzne
000137844 7001_ $$0P:(DE-2719)2813437$$aKoppara, Alexander$$b2$$udzne
000137844 7001_ $$0P:(DE-2719)2812139$$aKleineidam, Luca$$b3$$udzne
000137844 7001_ $$aSchmidtke, Klaus$$b4
000137844 7001_ $$aFrölich, Lutz$$b5
000137844 7001_ $$aKurz, Alexander$$b6
000137844 7001_ $$aSchulz, Stefanie$$b7
000137844 7001_ $$aHampel, Harald$$b8
000137844 7001_ $$aHeuser, Isabella$$b9
000137844 7001_ $$0P:(DE-HGF)0$$aPeters, Oliver$$b10
000137844 7001_ $$aReischies, Friedel M$$b11
000137844 7001_ $$aJahn, Holger$$b12
000137844 7001_ $$aLuckhaus, Christian$$b13
000137844 7001_ $$aHüll, Michael$$b14
000137844 7001_ $$aGertz, Hermann-Josef$$b15
000137844 7001_ $$aSchröder, Johannes$$b16
000137844 7001_ $$aPantel, Johannes$$b17
000137844 7001_ $$aRienhoff, Otto$$b18
000137844 7001_ $$0P:(DE-HGF)0$$aRüther, Eckart$$b19
000137844 7001_ $$aHenn, Fritz$$b20
000137844 7001_ $$0P:(DE-HGF)0$$aWiltfang, Jens$$b21
000137844 7001_ $$0P:(DE-2719)2000015$$aMaier, Wolfgang$$b22$$udzne
000137844 7001_ $$0P:(DE-HGF)0$$aKornhuber, Johannes$$b23
000137844 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b24$$eLast author$$udzne
000137844 77318 $$2Crossref$$3journal-article$$a10.1212/wnl.0000000000001399$$b : Ovid Technologies (Wolters Kluwer Health), 2015-02-25$$n12$$p1261-1268$$tNeurology$$v84$$x0028-3878$$y2015
000137844 773__ $$0PERI:(DE-600)1491874-2$$a10.1212/WNL.0000000000001399$$gVol. 84, no. 12, p. 1261 - 1268$$n12$$p1261-1268$$q84:12<1261 - 1268$$tNeurology$$v84$$x0028-3878$$y2015
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