TY  - JOUR
AU  - Wolfsgruber, Steffen
AU  - Jessen, Frank
AU  - Koppara, Alexander
AU  - Kleineidam, Luca
AU  - Schmidtke, Klaus
AU  - Frölich, Lutz
AU  - Kurz, Alexander
AU  - Schulz, Stefanie
AU  - Hampel, Harald
AU  - Heuser, Isabella
AU  - Peters, Oliver
AU  - Reischies, Friedel M
AU  - Jahn, Holger
AU  - Luckhaus, Christian
AU  - Hüll, Michael
AU  - Gertz, Hermann-Josef
AU  - Schröder, Johannes
AU  - Pantel, Johannes
AU  - Rienhoff, Otto
AU  - Rüther, Eckart
AU  - Henn, Fritz
AU  - Wiltfang, Jens
AU  - Maier, Wolfgang
AU  - Kornhuber, Johannes
AU  - Wagner, Michael
TI  - Subjective cognitive decline is related to CSF biomarkers of AD in patients with MCI.
JO  - Neurology
VL  - 84
IS  - 12
SN  - 0028-3878
CY  - [S.l.]
PB  - Ovid
M1  - DZNE-2020-04166
SP  - 1261-1268
PY  - 2015
AB  - To test whether, in individuals with mild cognitive impairment (MCI), different measures of subjective cognitive decline (SCD) in the memory domain predict abnormal CSF biomarkers of Alzheimer disease (AD).We analyzed the multicenter baseline (cross-sectional) data of 245 patients with MCI. SCD was measured quantitatively with the Subjective Memory Decline Scale (SMDS) and qualitatively by assessing particular concerns associated with self-experienced worsening of memory. Logistic regression models were used to examine associations between SCD and abnormal CSF biomarkers, taking into account objective memory impairment, depressive symptoms, and education as covariates.Abnormal CSF β-amyloid 1-42 (Aβ42) and more depressive symptoms were associated with higher SMDS scores and with the report of memory concerns. Risk of abnormal CSF Aβ42 increased by an estimated 57
KW  - Aged
KW  - Aged, 80 and over
KW  - Alzheimer Disease: cerebrospinal fluid
KW  - Alzheimer Disease: physiopathology
KW  - Alzheimer Disease: psychology
KW  - Amyloid beta-Peptides: cerebrospinal fluid
KW  - Biomarkers: cerebrospinal fluid
KW  - Cognitive Dysfunction: cerebrospinal fluid
KW  - Cognitive Dysfunction: physiopathology
KW  - Cognitive Dysfunction: psychology
KW  - Female
KW  - Humans
KW  - Male
KW  - Memory Disorders: cerebrospinal fluid
KW  - Memory Disorders: physiopathology
KW  - Memory Disorders: psychology
KW  - Middle Aged
KW  - Peptide Fragments: cerebrospinal fluid
KW  - Prodromal Symptoms
KW  - tau Proteins: cerebrospinal fluid
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - Peptide Fragments (NLM Chemicals)
KW  - amyloid beta-protein (1-42) (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25716354
DO  - DOI:10.1212/WNL.0000000000001399
UR  - https://pub.dzne.de/record/137844
ER  -