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@ARTICLE{Wolfsgruber:137844,
      author       = {Wolfsgruber, Steffen and Jessen, Frank and Koppara,
                      Alexander and Kleineidam, Luca and Schmidtke, Klaus and
                      Frölich, Lutz and Kurz, Alexander and Schulz, Stefanie and
                      Hampel, Harald and Heuser, Isabella and Peters, Oliver and
                      Reischies, Friedel M and Jahn, Holger and Luckhaus,
                      Christian and Hüll, Michael and Gertz, Hermann-Josef and
                      Schröder, Johannes and Pantel, Johannes and Rienhoff, Otto
                      and Rüther, Eckart and Henn, Fritz and Wiltfang, Jens and
                      Maier, Wolfgang and Kornhuber, Johannes and Wagner, Michael},
      title        = {{S}ubjective cognitive decline is related to {CSF}
                      biomarkers of {AD} in patients with {MCI}.},
      journal      = {Neurology},
      volume       = {84},
      number       = {12},
      issn         = {0028-3878},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {DZNE-2020-04166},
      pages        = {1261-1268},
      year         = {2015},
      abstract     = {To test whether, in individuals with mild cognitive
                      impairment (MCI), different measures of subjective cognitive
                      decline (SCD) in the memory domain predict abnormal CSF
                      biomarkers of Alzheimer disease (AD).We analyzed the
                      multicenter baseline (cross-sectional) data of 245 patients
                      with MCI. SCD was measured quantitatively with the
                      Subjective Memory Decline Scale (SMDS) and qualitatively by
                      assessing particular concerns associated with
                      self-experienced worsening of memory. Logistic regression
                      models were used to examine associations between SCD and
                      abnormal CSF biomarkers, taking into account objective
                      memory impairment, depressive symptoms, and education as
                      covariates.Abnormal CSF β-amyloid 1-42 (Aβ42) and more
                      depressive symptoms were associated with higher SMDS scores
                      and with the report of memory concerns. Risk of abnormal CSF
                      Aβ42 increased by an estimated $57\%$ for a 1-SD increase
                      in SMDS scores and was doubled in patients who had SMDS
                      scores >4 or who reported memory concerns, respectively. In
                      addition, both SCD measures predicted risk of having a
                      biomarker signature indicative of prodromal AD defined as
                      presence of low CSF Aβ42 together with either high CSF tau
                      or CSF phosphorylated tau 181 levels.In MCI, specific
                      aspects of SCD severity and quality are related to CSF
                      biomarkers indicative of AD. This extends findings in
                      pre-MCI samples and calls for an improved operational
                      assessment of SCD in MCI. This might be useful for sample
                      enrichment strategies for increased likelihood of AD
                      pathology.},
      keywords     = {Aged / Aged, 80 and over / Alzheimer Disease: cerebrospinal
                      fluid / Alzheimer Disease: physiopathology / Alzheimer
                      Disease: psychology / Amyloid beta-Peptides: cerebrospinal
                      fluid / Biomarkers: cerebrospinal fluid / Cognitive
                      Dysfunction: cerebrospinal fluid / Cognitive Dysfunction:
                      physiopathology / Cognitive Dysfunction: psychology / Female
                      / Humans / Male / Memory Disorders: cerebrospinal fluid /
                      Memory Disorders: physiopathology / Memory Disorders:
                      psychology / Middle Aged / Peptide Fragments: cerebrospinal
                      fluid / Prodromal Symptoms / tau Proteins: cerebrospinal
                      fluid / Amyloid beta-Peptides (NLM Chemicals) / Biomarkers
                      (NLM Chemicals) / Peptide Fragments (NLM Chemicals) /
                      amyloid beta-protein (1-42) (NLM Chemicals) / tau Proteins
                      (NLM Chemicals)},
      cin          = {AG Wagner / AG Jessen / U Clinical Researchers - Bonn},
      ddc          = {610},
      cid          = {I:(DE-2719)1011201 / I:(DE-2719)1011102 /
                      I:(DE-2719)7000001},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25716354},
      doi          = {10.1212/WNL.0000000000001399},
      url          = {https://pub.dzne.de/record/137844},
}