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000137851 0247_ $$2doi$$a10.1016/S1474-4422(15)70016-5
000137851 0247_ $$2pmid$$apmid:25792098
000137851 0247_ $$2pmc$$apmc:PMC5909703
000137851 0247_ $$2ISSN$$a1474-4422
000137851 0247_ $$2ISSN$$a1474-4465
000137851 0247_ $$2altmetric$$aaltmetric:3808150
000137851 037__ $$aDZNE-2020-04173
000137851 041__ $$aEnglish
000137851 082__ $$a610
000137851 1001_ $$0P:(DE-2719)2000008$$aHeneka, Michael$$b0$$eFirst author
000137851 245__ $$aNeuroinflammation in Alzheimer's disease.
000137851 260__ $$aLondon$$bLancet Publ. Group$$c2015
000137851 264_1 $$2Crossref$$3print$$bElsevier BV$$c2015-04-01
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000137851 520__ $$aIncreasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction. External factors, including systemic inflammation and obesity, are likely to interfere with immunological processes of the brain and further promote disease progression. Modulation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or preventive strategies for Alzheimer's disease.
000137851 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000137851 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x1
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000137851 650_7 $$2NLM Chemicals$$aAnti-Inflammatory Agents, Non-Steroidal
000137851 650_7 $$2NLM Chemicals$$aBiomarkers
000137851 650_7 $$2NLM Chemicals$$aInflammation Mediators
000137851 650_7 $$2NLM Chemicals$$aNootropic Agents
000137851 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000137851 650_2 $$2MeSH$$aAlzheimer Disease: immunology
000137851 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000137851 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000137851 650_2 $$2MeSH$$aAlzheimer Disease: prevention & control
000137851 650_2 $$2MeSH$$aAnimals
000137851 650_2 $$2MeSH$$aAnti-Inflammatory Agents, Non-Steroidal: therapeutic use
000137851 650_2 $$2MeSH$$aAstrocytes: immunology
000137851 650_2 $$2MeSH$$aAstrocytes: pathology
000137851 650_2 $$2MeSH$$aBiomarkers: blood
000137851 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000137851 650_2 $$2MeSH$$aBrain Injuries: complications
000137851 650_2 $$2MeSH$$aBrain Injuries: metabolism
000137851 650_2 $$2MeSH$$aClinical Trials as Topic
000137851 650_2 $$2MeSH$$aDisease Models, Animal
000137851 650_2 $$2MeSH$$aDisease Progression
000137851 650_2 $$2MeSH$$aHumans
000137851 650_2 $$2MeSH$$aImmunity, Innate
000137851 650_2 $$2MeSH$$aImmunization
000137851 650_2 $$2MeSH$$aInflammation: diagnosis
000137851 650_2 $$2MeSH$$aInflammation: immunology
000137851 650_2 $$2MeSH$$aInflammation: metabolism
000137851 650_2 $$2MeSH$$aInflammation Mediators: immunology
000137851 650_2 $$2MeSH$$aInflammation Mediators: metabolism
000137851 650_2 $$2MeSH$$aLocus Coeruleus: pathology
000137851 650_2 $$2MeSH$$aMicroglia: immunology
000137851 650_2 $$2MeSH$$aMicroglia: pathology
000137851 650_2 $$2MeSH$$aNootropic Agents: administration & dosage
000137851 650_2 $$2MeSH$$aObesity: complications
000137851 650_2 $$2MeSH$$aObesity: metabolism
000137851 650_2 $$2MeSH$$aPhagocytosis
000137851 650_2 $$2MeSH$$aProtein Folding
000137851 650_2 $$2MeSH$$aRisk Factors
000137851 650_2 $$2MeSH$$aSeverity of Illness Index
000137851 7001_ $$aCarson, Monica J$$b1
000137851 7001_ $$aEl Khoury, Joseph$$b2
000137851 7001_ $$aLandreth, Gary E$$b3
000137851 7001_ $$0P:(DE-2719)2810593$$aBrosseron, Frederic$$b4
000137851 7001_ $$aFeinstein, Douglas L$$b5
000137851 7001_ $$aJacobs, Andreas H$$b6
000137851 7001_ $$aWyss-Coray, Tony$$b7
000137851 7001_ $$aVitorica, Javier$$b8
000137851 7001_ $$aRansohoff, Richard M$$b9
000137851 7001_ $$aHerrup, Karl$$b10
000137851 7001_ $$aFrautschy, Sally A$$b11
000137851 7001_ $$aFinsen, Bente$$b12
000137851 7001_ $$aBrown, Guy C$$b13
000137851 7001_ $$aVerkhratsky, Alexei$$b14
000137851 7001_ $$aYamanaka, Koji$$b15
000137851 7001_ $$aKoistinaho, Jari$$b16
000137851 7001_ $$0P:(DE-2719)2000062$$aLatz, Eicke$$b17
000137851 7001_ $$0P:(DE-HGF)0$$aHalle, Annett$$b18
000137851 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b19
000137851 7001_ $$aTown, Terrence$$b20
000137851 7001_ $$aMorgan, Dave$$b21
000137851 7001_ $$aShinohara, Mari L$$b22
000137851 7001_ $$aPerry, V Hugh$$b23
000137851 7001_ $$aHolmes, Clive$$b24
000137851 7001_ $$aBazan, Nicolas G$$b25
000137851 7001_ $$aBrooks, David J$$b26
000137851 7001_ $$aHunot, Stéphane$$b27
000137851 7001_ $$aJoseph, Bertrand$$b28
000137851 7001_ $$aDeigendesch, Nikolaus$$b29
000137851 7001_ $$aGaraschuk, Olga$$b30
000137851 7001_ $$aBoddeke, Erik$$b31
000137851 7001_ $$aDinarello, Charles A$$b32
000137851 7001_ $$aBreitner, John C$$b33
000137851 7001_ $$aCole, Greg M$$b34
000137851 7001_ $$aGolenbock, Douglas T$$b35
000137851 7001_ $$0P:(DE-HGF)0$$aKummer, Markus P$$b36
000137851 77318 $$2Crossref$$3journal-article$$a10.1016/s1474-4422(15)70016-5$$b : Elsevier BV, 2015-04-01$$n4$$p388-405$$tThe Lancet Neurology$$v14$$x1474-4422$$y2015
000137851 773__ $$0PERI:(DE-600)2079704-7$$a10.1016/S1474-4422(15)70016-5$$gVol. 14, no. 4, p. 388 - 405$$n4$$p388-405$$q14:4<388 - 405$$tThe lancet <London> / Neurology$$v14$$x1474-4422$$y2015
000137851 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909703
000137851 8564_ $$uhttps://pub.dzne.de/record/137851/files/DZNE-2020-04173_Restricted.pdf
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