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000137882 0247_ $$2doi$$a10.1002/pmic.201400390
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000137882 037__ $$aDZNE-2020-04204
000137882 041__ $$aEnglish
000137882 082__ $$a540
000137882 1001_ $$aPorras, Pablo$$b0
000137882 245__ $$aA visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.
000137882 260__ $$aWeinheim$$bWiley VCH69157$$c2015
000137882 264_1 $$2Crossref$$3online$$bWiley$$c2015-03-21
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000137882 520__ $$aMolecular interaction databases are essential resources that enable access to a wealth of information on associations between proteins and other biomolecules. Network graphs generated from these data provide an understanding of the relationships between different proteins in the cell, and network analysis has become a widespread tool supporting -omics analysis. Meaningfully representing this information remains far from trivial and different databases strive to provide users with detailed records capturing the experimental details behind each piece of interaction evidence. A targeted curation approach is necessary to transfer published data generated by primarily low-throughput techniques into interaction databases. In this review we present an example highlighting the value of both targeted curation and the subsequent effective visualization of detailed features of manually curated interaction information. We have curated interactions involving LRRK2, a protein of largely unknown function linked to familial forms of Parkinson's disease, and hosted the data in the IntAct database. This LRRK2-specific dataset was then used to produce different visualization examples highlighting different aspects of the data: the level of confidence in the interaction based on orthogonal evidence, those interactions found under close-to-native conditions, and the enzyme-substrate relationships in different in vitro enzymatic assays. Finally, pathway annotation taken from the Reactome database was overlaid on top of interaction networks to bring biological functional context to interaction maps.
000137882 536__ $$0G:(DE-HGF)POF3-345$$a345 - Population Studies and Genetics (POF3-345)$$cPOF3-345$$fPOF III$$x0
000137882 542__ $$2Crossref$$i2015-09-01$$uhttp://doi.wiley.com/10.1002/tdm_license_1.1
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000137882 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aLRRK2 protein, human
000137882 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aLeucine-Rich Repeat Serine-Threonine Protein Kinase-2
000137882 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aProtein-Serine-Threonine Kinases
000137882 650_2 $$2MeSH$$aAnimals
000137882 650_2 $$2MeSH$$aComputer Graphics
000137882 650_2 $$2MeSH$$aDatabases, Protein
000137882 650_2 $$2MeSH$$aHumans
000137882 650_2 $$2MeSH$$aLeucine-Rich Repeat Serine-Threonine Protein Kinase-2
000137882 650_2 $$2MeSH$$aMolecular Sequence Annotation
000137882 650_2 $$2MeSH$$aParkinson Disease: metabolism
000137882 650_2 $$2MeSH$$aProtein Interaction Maps
000137882 650_2 $$2MeSH$$aProtein-Serine-Threonine Kinases: physiology
000137882 650_2 $$2MeSH$$aProteomics: methods
000137882 650_2 $$2MeSH$$aSoftware
000137882 7001_ $$aDuesbury, Margaret$$b1
000137882 7001_ $$aFabregat, Antonio$$b2
000137882 7001_ $$aUeffing, Marius$$b3
000137882 7001_ $$aOrchard, Sandra$$b4
000137882 7001_ $$0P:(DE-2719)2811291$$aGloeckner, Christian Johannes$$b5$$eCorresponding author$$udzne
000137882 7001_ $$aHermjakob, Henning$$b6
000137882 77318 $$2Crossref$$3journal-article$$a10.1002/pmic.201400390$$b : Wiley, 2015-03-21$$n8$$p1390-1404$$tPROTEOMICS$$v15$$x1615-9853$$y2015
000137882 773__ $$0PERI:(DE-600)2253166-X$$a10.1002/pmic.201400390$$gVol. 15, no. 8, p. 1390 - 1404$$n8$$p1390-1404$$q15:8<1390 - 1404$$tPractical proteomics$$v15$$x1615-9853$$y2015
000137882 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415485
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