TY  - JOUR
AU  - Benito, Eva
AU  - Barco, Angel
TI  - The neuronal activity-driven transcriptome.
JO  - Molecular neurobiology
VL  - 51
IS  - 3
SN  - 0893-7648
CY  - Totowa, NJ
PB  - Humana Press
M1  - DZNE-2020-04255
SP  - 1071-1088
PY  - 2015
AB  - Activity-driven transcription is a key event associated with long-lasting forms of neuronal plasticity. Despite the efforts to investigate the regulatory mechanisms that control this complex process and the important advances in the knowledge of the function of many activity-induced genes in neurons, as well as the specific contribution of activity-regulated transcription factors, our understanding of how activity-driven transcription operates at the systems biology level is still very limited. This review focuses on the research of neuronal activity-driven transcription from an 'omics' perspective. We will discuss the different high-throughput approaches undertaken to characterize the gene programs downstream of specific activity-regulated transcription factors, including CREB, SRF, MeCP2, Fos, Npas4, and others, and the interplay between epigenetic and transcriptional mechanisms underlying neuronal plasticity changes. Although basic questions remain unanswered and important challenges still lie ahead, the refinement of genome-wide techniques for investigating the neuronal transcriptome and epigenome promises great advances.
KW  - Animals
KW  - Gene Expression Profiling: trends
KW  - Genome-Wide Association Study: trends
KW  - Humans
KW  - Neurons: physiology
KW  - Transcriptome: physiology
LB  - PUB:(DE-HGF)16
C6  - pmid:24935719
DO  - DOI:10.1007/s12035-014-8772-z
UR  - https://pub.dzne.de/record/137933
ER  -