000137972 001__ 137972 000137972 005__ 20240321220341.0 000137972 0247_ $$2doi$$a10.7554/eLife.06426 000137972 0247_ $$2pmid$$apmid:26052749 000137972 0247_ $$2pmc$$apmc:PMC4458841 000137972 0247_ $$2altmetric$$aaltmetric:4115791 000137972 037__ $$aDZNE-2020-04294 000137972 041__ $$aEnglish 000137972 082__ $$a600 000137972 1001_ $$0P:(DE-2719)2811815$$aMaaß, Anne$$b0$$eFirst author 000137972 245__ $$aFunctional subregions of the human entorhinal cortex. 000137972 260__ $$aCambridge$$beLife Sciences Publications$$c2015 000137972 264_1 $$2Crossref$$3online$$beLife Sciences Publications, Ltd$$c2015-06-08 000137972 3367_ $$2DRIVER$$aarticle 000137972 3367_ $$2DataCite$$aOutput Types/Journal article 000137972 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1709718365_11500 000137972 3367_ $$2BibTeX$$aARTICLE 000137972 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000137972 3367_ $$00$$2EndNote$$aJournal Article 000137972 520__ $$aThe entorhinal cortex (EC) is the primary site of interactions between the neocortex and hippocampus. Studies in rodents and nonhuman primates suggest that EC can be divided into subregions that connect differentially with perirhinal cortex (PRC) vs parahippocampal cortex (PHC) and with hippocampal subfields along the proximo-distal axis. Here, we used high-resolution functional magnetic resonance imaging at 7 Tesla to identify functional subdivisions of the human EC. In two independent datasets, PRC showed preferential intrinsic functional connectivity with anterior-lateral EC and PHC with posterior-medial EC. These EC subregions, in turn, exhibited differential connectivity with proximal and distal subiculum. In contrast, connectivity of PRC and PHC with subiculum followed not only a proximal-distal but also an anterior-posterior gradient. Our data provide the first evidence that the human EC can be divided into functional subdivisions whose functional connectivity closely parallels the known anatomical connectivity patterns of the rodent and nonhuman primate EC. 000137972 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0 000137972 542__ $$2Crossref$$i2015-06-08$$uhttp://creativecommons.org/licenses/by/4.0/ 000137972 588__ $$aDataset connected to CrossRef, PubMed, 000137972 650_2 $$2MeSH$$aAdult 000137972 650_2 $$2MeSH$$aConnectome: methods 000137972 650_2 $$2MeSH$$aEntorhinal Cortex: anatomy & histology 000137972 650_2 $$2MeSH$$aEntorhinal Cortex: physiology 000137972 650_2 $$2MeSH$$aFemale 000137972 650_2 $$2MeSH$$aHippocampus: physiology 000137972 650_2 $$2MeSH$$aHumans 000137972 650_2 $$2MeSH$$aMagnetic Resonance Imaging 000137972 650_2 $$2MeSH$$aMale 000137972 650_2 $$2MeSH$$aMemory: physiology 000137972 650_2 $$2MeSH$$aNeural Pathways: physiology 000137972 650_2 $$2MeSH$$aSpecies Specificity 000137972 650_2 $$2MeSH$$aVisual Perception: physiology 000137972 7001_ $$0P:(DE-2719)2812972$$aBerron, David$$b1 000137972 7001_ $$0P:(DE-HGF)0$$aLibby, Laura A$$b2 000137972 7001_ $$0P:(DE-HGF)0$$aRanganath, Charan$$b3 000137972 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b4$$eLast author 000137972 77318 $$2Crossref$$3journal-article$$a10.7554/elife.06426$$b : eLife Sciences Publications, Ltd, 2015-06-08$$teLife$$v4$$x2050-084X$$y2015 000137972 773__ $$0PERI:(DE-600)2687154-3$$a10.7554/eLife.06426$$gVol. 4, p. e06426$$pe06426$$q4<e06426$$teLife$$v4$$x2050-084X$$y2015 000137972 8564_ $$uhttps://elifesciences.org/articles/06426#fig1 000137972 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458841 000137972 8564_ $$uhttps://pub.dzne.de/record/137972/files/656_fig.pdf 000137972 8564_ $$uhttps://pub.dzne.de/record/137972/files/656.pdf$$yOpenAccess 000137972 8564_ 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