TY  - JOUR
AU  - Maaß, Anne
AU  - Berron, David
AU  - Libby, Laura A
AU  - Ranganath, Charan
AU  - Düzel, Emrah
TI  - Functional subregions of the human entorhinal cortex.
JO  - eLife
VL  - 4
SN  - 2050-084X
CY  - Cambridge
PB  - eLife Sciences Publications
M1  - DZNE-2020-04294
SP  - e06426
PY  - 2015
AB  - The entorhinal cortex (EC) is the primary site of interactions between the neocortex and hippocampus. Studies in rodents and nonhuman primates suggest that EC can be divided into subregions that connect differentially with perirhinal cortex (PRC) vs parahippocampal cortex (PHC) and with hippocampal subfields along the proximo-distal axis. Here, we used high-resolution functional magnetic resonance imaging at 7 Tesla to identify functional subdivisions of the human EC. In two independent datasets, PRC showed preferential intrinsic functional connectivity with anterior-lateral EC and PHC with posterior-medial EC. These EC subregions, in turn, exhibited differential connectivity with proximal and distal subiculum. In contrast, connectivity of PRC and PHC with subiculum followed not only a proximal-distal but also an anterior-posterior gradient. Our data provide the first evidence that the human EC can be divided into functional subdivisions whose functional connectivity closely parallels the known anatomical connectivity patterns of the rodent and nonhuman primate EC.
KW  - Adult
KW  - Connectome: methods
KW  - Entorhinal Cortex: anatomy & histology
KW  - Entorhinal Cortex: physiology
KW  - Female
KW  - Hippocampus: physiology
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Memory: physiology
KW  - Neural Pathways: physiology
KW  - Species Specificity
KW  - Visual Perception: physiology
LB  - PUB:(DE-HGF)16
C6  - pmid:26052749
C2  - pmc:PMC4458841
DO  - DOI:10.7554/eLife.06426
UR  - https://pub.dzne.de/record/137972
ER  -