TY  - JOUR
AU  - Hagen, Katja
AU  - Ehlis, Ann-Christine
AU  - Haeussinger, Florian B
AU  - Beeretz, Stefan
AU  - Kromer, Gina V
AU  - Heinzel, Sebastian
AU  - Maetzler, Walter
AU  - Eschweiler, Gerhard W
AU  - Berg, Daniela
AU  - Fallgatter, Andreas J
AU  - Metzger, Florian G
AU  - Consortium, TREND Study
TI  - The relation of SMI and the VSEP in a risk sample for neurodegenerative disorders.
JO  - Journal of neural transmission
VL  - 122
IS  - 8
SN  - 0300-9564
CY  - Wien [u.a.]
PB  - Springer
M1  - DZNE-2020-04352
SP  - 1167-1174
PY  - 2015
AB  - Vagus somatosensory evoked potentials (VSEP) have been shown to have higher latencies with aging, which are even more increased in patients with Alzheimer's disease and subjects with mild cognitive impairment compared to age-matched healthy controls. In this study, the association of VSEP with subjective memory impairment (SMI), a potential risk or prodromal marker for Alzheimer's disease, was examined. The association of VSEP latencies and SMI was studied in a healthy risk cohort, including 358 elderly subjects, who are in a longitudinal study of risk factors for neurodegenerative disorders. The results show increased VSEP latencies for peak P2 at Fz-F4 in subjects who report SMI and are worried about it as compared to subjects who report memory impairment, but are not concerned and subjects without complaints. The results support a potential role of VSEP for the detection of very early neurodegenerative processes which may precede Alzheimer's disease.
KW  - Alzheimer Disease: diagnosis
KW  - Cognitive Dysfunction: diagnosis
KW  - Evoked Potentials, Somatosensory: drug effects
KW  - Evoked Potentials, Somatosensory: physiology
KW  - Female
KW  - Humans
KW  - Male
KW  - Memory Disorders: drug therapy
KW  - Memory Disorders: physiopathology
KW  - Middle Aged
KW  - Neurodegenerative Diseases: diagnosis
KW  - Neurodegenerative Diseases: drug therapy
KW  - Neurodegenerative Diseases: physiopathology
KW  - Perception
KW  - Prospective Studies
KW  - Risk
KW  - Vagus Nerve: drug effects
KW  - Vagus Nerve: physiopathology
LB  - PUB:(DE-HGF)16
C6  - pmid:25520210
DO  - DOI:10.1007/s00702-014-1351-7
UR  - https://pub.dzne.de/record/138030
ER  -