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@ARTICLE{Hagen:138030,
      author       = {Hagen, Katja and Ehlis, Ann-Christine and Haeussinger,
                      Florian B and Beeretz, Stefan and Kromer, Gina V and
                      Heinzel, Sebastian and Maetzler, Walter and Eschweiler,
                      Gerhard W and Berg, Daniela and Fallgatter, Andreas J and
                      Metzger, Florian G and Consortium, TREND Study},
      title        = {{T}he relation of {SMI} and the {VSEP} in a risk sample for
                      neurodegenerative disorders.},
      journal      = {Journal of neural transmission},
      volume       = {122},
      number       = {8},
      issn         = {0300-9564},
      address      = {Wien [u.a.]},
      publisher    = {Springer},
      reportid     = {DZNE-2020-04352},
      pages        = {1167-1174},
      year         = {2015},
      abstract     = {Vagus somatosensory evoked potentials (VSEP) have been
                      shown to have higher latencies with aging, which are even
                      more increased in patients with Alzheimer's disease and
                      subjects with mild cognitive impairment compared to
                      age-matched healthy controls. In this study, the association
                      of VSEP with subjective memory impairment (SMI), a potential
                      risk or prodromal marker for Alzheimer's disease, was
                      examined. The association of VSEP latencies and SMI was
                      studied in a healthy risk cohort, including 358 elderly
                      subjects, who are in a longitudinal study of risk factors
                      for neurodegenerative disorders. The results show increased
                      VSEP latencies for peak P2 at Fz-F4 in subjects who report
                      SMI and are worried about it as compared to subjects who
                      report memory impairment, but are not concerned and subjects
                      without complaints. The results support a potential role of
                      VSEP for the detection of very early neurodegenerative
                      processes which may precede Alzheimer's disease.},
      keywords     = {Alzheimer Disease: diagnosis / Cognitive Dysfunction:
                      diagnosis / Evoked Potentials, Somatosensory: drug effects /
                      Evoked Potentials, Somatosensory: physiology / Female /
                      Humans / Male / Memory Disorders: drug therapy / Memory
                      Disorders: physiopathology / Middle Aged / Neurodegenerative
                      Diseases: diagnosis / Neurodegenerative Diseases: drug
                      therapy / Neurodegenerative Diseases: physiopathology /
                      Perception / Prospective Studies / Risk / Vagus Nerve: drug
                      effects / Vagus Nerve: physiopathology},
      cin          = {AG N.N. 3 / AG Maetzler / AG Berg ; AG Berg},
      ddc          = {610},
      cid          = {I:(DE-2719)1240015 / I:(DE-2719)5000024 /
                      I:(DE-2719)5000055},
      pnm          = {344 - Clinical and Health Care Research (POF3-344) / 345 -
                      Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25520210},
      doi          = {10.1007/s00702-014-1351-7},
      url          = {https://pub.dzne.de/record/138030},
}