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000138043 0247_ $$2doi$$a10.1016/j.neurobiolaging.2015.05.013
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000138043 041__ $$aEnglish
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000138043 1001_ $$0P:(DE-2719)9000287$$aSchmitz, Matthias$$b0
000138043 245__ $$aCytokine profiles and the role of cellular prion protein in patients with vascular dementia and vascular encephalopathy.
000138043 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2015
000138043 264_1 $$2Crossref$$3print$$bElsevier BV$$c2015-09-01
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000138043 520__ $$aUnderstanding inflammatory mechanisms in vascular dementia (VD) is pivotal for achieving better insights into changes in brain metabolism. We performed cytokine profiling and measured levels of the cellular prion protein (PrP(C)) in serum and cerebrospinal fluid (CSF) samples from patients with VD and with vascular encephalopathy (VE). Significant changes were observed for interleukin (IL)-1β, IL-4, IL-5, tumor necrosis factor alpha, interferon gamma, granulocyte-colony stimulating factor, monocyte chemotactic protein 1, and macrophage inflammatory protein 1 beta in serum and for IL-6 and granulocyte macrophage colony-stimulating factor in CSF of VD and VE patients, suggesting that most of immune markers depend on vascular lesions, while only IL-6 was related to dementia. In VD patients, the severity of dementia as defined by the Mini-Mental Status Test or Cambridge Cognitive Examination battery test was significantly correlated with the levels of IL-8 (CSF) and macrophage inflammatory protein 1 beta (serum and CSF). Additionally, in CSF of VD patients, our data revealed a correlation between immune and neurodegenerative marker proteins. Both indicate an association of neuroinflammation and cognitive decline. Levels of PrP(C) were regulated differentially in VD and VE patients compared with Alzheimer's disease patients and controls. Moreover, we observed a significant negative correlation between cytokine levels and PrP(C) in VD patients in CSF and serum, as well as a correlation between PrP(C) expression with levels of neurodegenerative marker proteins in CSF (in VD and VE patients). Our data suggest that immunological modifiers play a role in VD and VE patients and provide evidence for an association of PrP(C) with immune and neurodegenerative markers.
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000138043 542__ $$2Crossref$$i2015-09-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
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000138043 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000138043 650_7 $$2NLM Chemicals$$aCytokines
000138043 650_7 $$2NLM Chemicals$$aPeptide Fragments
000138043 650_7 $$2NLM Chemicals$$aPrions
000138043 650_7 $$2NLM Chemicals$$aamyloid beta-protein (1-40)
000138043 650_7 $$2NLM Chemicals$$aamyloid beta-protein (1-42)
000138043 650_7 $$2NLM Chemicals$$atau Proteins
000138043 650_2 $$2MeSH$$aAdult
000138043 650_2 $$2MeSH$$aAged
000138043 650_2 $$2MeSH$$aAged, 80 and over
000138043 650_2 $$2MeSH$$aAmyloid beta-Peptides: cerebrospinal fluid
000138043 650_2 $$2MeSH$$aCerebrovascular Disorders: cerebrospinal fluid
000138043 650_2 $$2MeSH$$aCohort Studies
000138043 650_2 $$2MeSH$$aCytokines: cerebrospinal fluid
000138043 650_2 $$2MeSH$$aDementia, Vascular: cerebrospinal fluid
000138043 650_2 $$2MeSH$$aEnzyme-Linked Immunosorbent Assay
000138043 650_2 $$2MeSH$$aFemale
000138043 650_2 $$2MeSH$$aHumans
000138043 650_2 $$2MeSH$$aLinear Models
000138043 650_2 $$2MeSH$$aMale
000138043 650_2 $$2MeSH$$aMental Status Schedule
000138043 650_2 $$2MeSH$$aMiddle Aged
000138043 650_2 $$2MeSH$$aNeuropsychological Tests
000138043 650_2 $$2MeSH$$aPeptide Fragments: cerebrospinal fluid
000138043 650_2 $$2MeSH$$aPrions: cerebrospinal fluid
000138043 650_2 $$2MeSH$$atau Proteins: cerebrospinal fluid
000138043 7001_ $$0P:(DE-2719)2812183$$aHermann, Peter$$b1
000138043 7001_ $$0P:(DE-2719)9000239$$aOikonomou, Panteleimon$$b2
000138043 7001_ $$0P:(DE-2719)9000304$$aStoeck, Katharina$$b3
000138043 7001_ $$0P:(DE-2719)9000063$$aEbert, Elisabeth$$b4
000138043 7001_ $$0P:(DE-HGF)0$$aPoliakova, Tatjana$$b5
000138043 7001_ $$0P:(DE-2719)9000950$$aSchmidt, Christian$$b6$$udzne
000138043 7001_ $$0P:(DE-2719)2811280$$aLlorens, Franc$$b7
000138043 7001_ $$0P:(DE-2719)9000358$$aZafar, Saima$$b8
000138043 7001_ $$0P:(DE-2719)2000058$$aZerr, Inga$$b9$$eLast author
000138043 77318 $$2Crossref$$3journal-article$$a10.1016/j.neurobiolaging.2015.05.013$$b : Elsevier BV, 2015-09-01$$n9$$p2597-2606$$tNeurobiology of Aging$$v36$$x0197-4580$$y2015
000138043 773__ $$0PERI:(DE-600)1498414-3$$a10.1016/j.neurobiolaging.2015.05.013$$gVol. 36, no. 9, p. 2597 - 2606$$n9$$p2597-2606$$q36:9<2597 - 2606$$tNeurobiology of aging$$v36$$x0197-4580$$y2015
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