TY  - JOUR
AU  - Schmitz, Matthias
AU  - Hermann, Peter
AU  - Oikonomou, Panteleimon
AU  - Stoeck, Katharina
AU  - Ebert, Elisabeth
AU  - Poliakova, Tatjana
AU  - Schmidt, Christian
AU  - Llorens, Franc
AU  - Zafar, Saima
AU  - Zerr, Inga
TI  - Cytokine profiles and the role of cellular prion protein in patients with vascular dementia and vascular encephalopathy.
JO  - Neurobiology of aging
VL  - 36
IS  - 9
SN  - 0197-4580
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2020-04365
SP  - 2597-2606
PY  - 2015
AB  - Understanding inflammatory mechanisms in vascular dementia (VD) is pivotal for achieving better insights into changes in brain metabolism. We performed cytokine profiling and measured levels of the cellular prion protein (PrP(C)) in serum and cerebrospinal fluid (CSF) samples from patients with VD and with vascular encephalopathy (VE). Significant changes were observed for interleukin (IL)-1β, IL-4, IL-5, tumor necrosis factor alpha, interferon gamma, granulocyte-colony stimulating factor, monocyte chemotactic protein 1, and macrophage inflammatory protein 1 beta in serum and for IL-6 and granulocyte macrophage colony-stimulating factor in CSF of VD and VE patients, suggesting that most of immune markers depend on vascular lesions, while only IL-6 was related to dementia. In VD patients, the severity of dementia as defined by the Mini-Mental Status Test or Cambridge Cognitive Examination battery test was significantly correlated with the levels of IL-8 (CSF) and macrophage inflammatory protein 1 beta (serum and CSF). Additionally, in CSF of VD patients, our data revealed a correlation between immune and neurodegenerative marker proteins. Both indicate an association of neuroinflammation and cognitive decline. Levels of PrP(C) were regulated differentially in VD and VE patients compared with Alzheimer's disease patients and controls. Moreover, we observed a significant negative correlation between cytokine levels and PrP(C) in VD patients in CSF and serum, as well as a correlation between PrP(C) expression with levels of neurodegenerative marker proteins in CSF (in VD and VE patients). Our data suggest that immunological modifiers play a role in VD and VE patients and provide evidence for an association of PrP(C) with immune and neurodegenerative markers.
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Amyloid beta-Peptides: cerebrospinal fluid
KW  - Cerebrovascular Disorders: cerebrospinal fluid
KW  - Cohort Studies
KW  - Cytokines: cerebrospinal fluid
KW  - Dementia, Vascular: cerebrospinal fluid
KW  - Enzyme-Linked Immunosorbent Assay
KW  - Female
KW  - Humans
KW  - Linear Models
KW  - Male
KW  - Mental Status Schedule
KW  - Middle Aged
KW  - Neuropsychological Tests
KW  - Peptide Fragments: cerebrospinal fluid
KW  - Prions: cerebrospinal fluid
KW  - tau Proteins: cerebrospinal fluid
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Cytokines (NLM Chemicals)
KW  - Peptide Fragments (NLM Chemicals)
KW  - Prions (NLM Chemicals)
KW  - amyloid beta-protein (1-40) (NLM Chemicals)
KW  - amyloid beta-protein (1-42) (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26170132
DO  - DOI:10.1016/j.neurobiolaging.2015.05.013
UR  - https://pub.dzne.de/record/138043
ER  -