Home > Publications Database > Cytokine profiles and the role of cellular prion protein in patients with vascular dementia and vascular encephalopathy. > print

001     138043
005     20240321220348.0
024 7 _ |a 10.1016/j.neurobiolaging.2015.05.013
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024 7 _ |a pmid:26170132
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024 7 _ |a 0197-4580
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024 7 _ |a 1558-1497
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037 _ _ |a DZNE-2020-04365
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Schmitz, Matthias
|0 P:(DE-2719)9000287
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245 _ _ |a Cytokine profiles and the role of cellular prion protein in patients with vascular dementia and vascular encephalopathy.
260 _ _ |a Amsterdam [u.a.]
|c 2015
|b Elsevier Science
264 _ 1 |3 print
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|b Elsevier BV
|c 2015-09-01
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Understanding inflammatory mechanisms in vascular dementia (VD) is pivotal for achieving better insights into changes in brain metabolism. We performed cytokine profiling and measured levels of the cellular prion protein (PrP(C)) in serum and cerebrospinal fluid (CSF) samples from patients with VD and with vascular encephalopathy (VE). Significant changes were observed for interleukin (IL)-1β, IL-4, IL-5, tumor necrosis factor alpha, interferon gamma, granulocyte-colony stimulating factor, monocyte chemotactic protein 1, and macrophage inflammatory protein 1 beta in serum and for IL-6 and granulocyte macrophage colony-stimulating factor in CSF of VD and VE patients, suggesting that most of immune markers depend on vascular lesions, while only IL-6 was related to dementia. In VD patients, the severity of dementia as defined by the Mini-Mental Status Test or Cambridge Cognitive Examination battery test was significantly correlated with the levels of IL-8 (CSF) and macrophage inflammatory protein 1 beta (serum and CSF). Additionally, in CSF of VD patients, our data revealed a correlation between immune and neurodegenerative marker proteins. Both indicate an association of neuroinflammation and cognitive decline. Levels of PrP(C) were regulated differentially in VD and VE patients compared with Alzheimer's disease patients and controls. Moreover, we observed a significant negative correlation between cytokine levels and PrP(C) in VD patients in CSF and serum, as well as a correlation between PrP(C) expression with levels of neurodegenerative marker proteins in CSF (in VD and VE patients). Our data suggest that immunological modifiers play a role in VD and VE patients and provide evidence for an association of PrP(C) with immune and neurodegenerative markers.
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542 _ _ |i 2015-09-01
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650 _ 7 |a Amyloid beta-Peptides
|2 NLM Chemicals
650 _ 7 |a Cytokines
|2 NLM Chemicals
650 _ 7 |a Peptide Fragments
|2 NLM Chemicals
650 _ 7 |a Prions
|2 NLM Chemicals
650 _ 7 |a amyloid beta-protein (1-40)
|2 NLM Chemicals
650 _ 7 |a amyloid beta-protein (1-42)
|2 NLM Chemicals
650 _ 7 |a tau Proteins
|2 NLM Chemicals
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Amyloid beta-Peptides: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Cerebrovascular Disorders: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Cohort Studies
|2 MeSH
650 _ 2 |a Cytokines: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Dementia, Vascular: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Enzyme-Linked Immunosorbent Assay
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Linear Models
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Mental Status Schedule
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Neuropsychological Tests
|2 MeSH
650 _ 2 |a Peptide Fragments: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Prions: cerebrospinal fluid
|2 MeSH
650 _ 2 |a tau Proteins: cerebrospinal fluid
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700 1 _ |a Hermann, Peter
|0 P:(DE-2719)2812183
|b 1
700 1 _ |a Oikonomou, Panteleimon
|0 P:(DE-2719)9000239
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700 1 _ |a Stoeck, Katharina
|0 P:(DE-2719)9000304
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700 1 _ |a Ebert, Elisabeth
|0 P:(DE-2719)9000063
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700 1 _ |a Poliakova, Tatjana
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700 1 _ |a Schmidt, Christian
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700 1 _ |a Llorens, Franc
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700 1 _ |a Zafar, Saima
|0 P:(DE-2719)9000358
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700 1 _ |a Zerr, Inga
|0 P:(DE-2719)2000058
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773 1 8 |a 10.1016/j.neurobiolaging.2015.05.013
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|t Neurobiology of Aging
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773 _ _ |a 10.1016/j.neurobiolaging.2015.05.013
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