TY  - JOUR
AU  - Stucht, Daniel
AU  - Danishad, K Appu
AU  - Schulze, Peter
AU  - Godenschweger, Frank
AU  - Zaitsev, Maxim
AU  - Speck, Oliver
TI  - Highest Resolution In Vivo Human Brain MRI Using Prospective Motion Correction.
JO  - PLOS ONE
VL  - 10
IS  - 7
SN  - 1932-6203
CY  - San Francisco, California, US
PB  - PLOS
M1  - DZNE-2020-04366
SP  - e0133921
PY  - 2015
AB  - High field MRI systems, such as 7 Tesla (T) scanners, can deliver higher signal to noise ratio (SNR) than lower field scanners and thus allow for the acquisition of data with higher spatial resolution, which is often demanded by users in the fields of clinical and neuroscientific imaging. However, high resolution scans may require long acquisition times, which in turn increase the discomfort for the subject and the risk of subject motion. Even with a cooperative and trained subject, involuntary motion due to heartbeat, swallowing, respiration and changes in muscle tone can cause image artifacts that reduce the effective resolution. In addition, scanning with higher resolution leads to increased sensitivity to even very small movements. Prospective motion correction (PMC) at 3T and 7T has proven to increase image quality in case of subject motion. Although the application of prospective motion correction is becoming more popular, previous articles focused on proof of concept studies and technical descriptions, whereas this paper briefly describes the technical aspects of the optical tracking system, marker fixation and cross calibration and focuses on the application of PMC to very high resolution imaging without intentional motion. In this study we acquired in vivo MR images at 7T using prospective motion correction during long acquisitions. As a result, we present images among the highest, if not the highest resolution of in vivo human brain MRI ever acquired.
KW  - Artifacts
KW  - Brain: physiology
KW  - Calibration
KW  - Equipment Design: methods
KW  - Humans
KW  - Image Processing, Computer-Assisted: methods
KW  - Magnetic Resonance Imaging: methods
KW  - Motion
KW  - Movement: physiology
KW  - Prospective Studies
KW  - Respiration
LB  - PUB:(DE-HGF)16
C6  - pmid:26226146
C2  - pmc:PMC4520483
DO  - DOI:10.1371/journal.pone.0133921
UR  - https://pub.dzne.de/record/138044
ER  -