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| 001 | 138071 | ||
| 005 | 20240601120429.0 | ||
| 024 | 7 | _ | |a 10.1186/s12881-015-0198-6 |2 doi |
| 024 | 7 | _ | |a pmid:26286599 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4593209 |2 pmc |
| 024 | 7 | _ | |a altmetric:4417329 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-04393 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Park, Suyeon |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families. |
| 260 | _ | _ | |a Heidelberg |c 2015 |b Springer |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2015-08-19 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2015-12-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1717155357_12092 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a In family-based association analysis, each family is typically ascertained from a single proband, which renders the effects of ascertainment bias heterogeneous among family members. This is contrary to case-control studies, and may introduce sample or ascertainment bias. Statistical efficiency is affected by ascertainment bias, and careful adjustment can lead to substantial improvements in statistical power. However, genetic association analysis has often been conducted using family-based designs, without addressing the fact that each proband in a family has had a great influence on the probability for each family member to be affected.We propose a powerful and efficient statistic for genetic association analysis that considered the heterogeneity of ascertainment bias among family members, under the assumption that both prevalence and heritability of disease are available. With extensive simulation studies, we showed that the proposed method performed better than the existing methods, particularly for diseases with large heritability.We applied the proposed method to the genome-wide association analysis of Alzheimer's disease. Four significant associations with the proposed method were found.Our significant findings illustrated the practical importance of this new analysis method. |
| 536 | _ | _ | |a 345 - Population Studies and Genetics (POF3-345) |0 G:(DE-HGF)POF3-345 |c POF3-345 |f POF III |x 0 |
| 542 | _ | _ | |i 2015-08-19 |2 Crossref |u http://www.springer.com/tdm |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 2 | |a Alzheimer Disease: genetics |2 MeSH |
| 650 | _ | 2 | |a Computer Simulation |2 MeSH |
| 650 | _ | 2 | |a Data Interpretation, Statistical |2 MeSH |
| 650 | _ | 2 | |a Family |2 MeSH |
| 650 | _ | 2 | |a Gene Frequency |2 MeSH |
| 650 | _ | 2 | |a Genetic Association Studies: methods |2 MeSH |
| 650 | _ | 2 | |a Genetic Heterogeneity |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Selection Bias |2 MeSH |
| 700 | 1 | _ | |a Lee, Sungyoung |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Lee, Young |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Herold, Christine |0 P:(DE-2719)2802016 |b 3 |u dzne |
| 700 | 1 | _ | |a Hooli, Basavaraj |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Mullin, Kristina |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Park, Taesung |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Park, Changsoon |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Bertram, Lars |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Lange, Christoph |0 P:(DE-2719)9000181 |b 9 |u dzne |
| 700 | 1 | _ | |a Tanzi, Rudolph |0 P:(DE-HGF)0 |b 10 |e Corresponding author |
| 700 | 1 | _ | |a Won, Sungho |0 P:(DE-HGF)0 |b 11 |
| 773 | 1 | 8 | |a 10.1186/s12881-015-0198-6 |b : Springer Science and Business Media LLC, 2015-08-19 |n 1 |p 62 |3 journal-article |2 Crossref |t BMC Medical Genetics |v 16 |y 2015 |x 1471-2350 |
| 773 | _ | _ | |a 10.1186/s12881-015-0198-6 |g Vol. 16, no. 1, p. 62 |0 PERI:(DE-600)2041359-2 |n 1 |q 16:1<62 |p 62 |t BMC medical genetics |v 16 |y 2015 |x 1471-2350 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/138071/files/DZNE-2020-04393.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/138071/files/DZNE-2020-04393.pdf?subformat=pdfa |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593209 |
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| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/456018a |2 Crossref |o 10.1038/456018a |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature08494 |2 Crossref |o 10.1038/nature08494 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ng0508-489 |2 Crossref |o 10.1038/ng0508-489 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1056/NEJM199508103330605 |2 Crossref |o 10.1056/NEJM199508103330605 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/(SICI)1098-2272(1997)14:6<791::AID-GEPI38>3.0.CO;2-J |2 Crossref |o 10.1002/(SICI)1098-2272(1997)14:6<791::AID-GEPI38>3.0.CO;2-J |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1515/CCLM.2009.284 |2 Crossref |o 10.1515/CCLM.2009.284 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1097/MOL.0b013e328336eae9 |2 Crossref |o 10.1097/MOL.0b013e328336eae9 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.ajhg.2008.06.024 |2 Crossref |o 10.1016/j.ajhg.2008.06.024 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1086/302900 |2 Crossref |o 10.1086/302900 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1186/1471-2350-9-4 |2 Crossref |o 10.1186/1471-2350-9-4 |
| 999 | C | 5 | |y 1995 |2 Crossref |o N Risch 1995 |
| 999 | C | 5 | |y 1996 |2 Crossref |o NJ Risch 1996 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.0812824106 |2 Crossref |o 10.1073/pnas.0812824106 |
| 999 | C | 5 | |y 1989 |2 Crossref |o ES Lander 1989 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1023/A:1001907321955 |2 Crossref |o 10.1023/A:1001907321955 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.2307/2533494 |2 Crossref |o 10.2307/2533494 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/sim.5865 |2 Crossref |o 10.1002/sim.5865 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1086/519497 |2 Crossref |o 10.1086/519497 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1469-1809.1967.tb02015.x |2 Crossref |o 10.1111/j.1469-1809.1967.tb02015.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1086/519795 |2 Crossref |o 10.1086/519795 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.ajhg.2010.11.011 |2 Crossref |o 10.1016/j.ajhg.2010.11.011 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1086/344696 |2 Crossref |o 10.1086/344696 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.0006-341X.2004.00180.x |2 Crossref |o 10.1111/j.0006-341X.2004.00180.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s00439-013-1334-z |2 Crossref |o 10.1007/s00439-013-1334-z |
| 999 | C | 5 | |y 1989 |2 Crossref |o P Leppard 1989 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1017/S0013091500008063 |2 Crossref |o 10.1017/S0013091500008063 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1098/rsta.1903.0001 |2 Crossref |o 10.1098/rsta.1903.0001 |
| 999 | C | 5 | |y 1979 |2 Crossref |o RC Elston 1979 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1001/archpsyc.63.2.168 |2 Crossref |o 10.1001/archpsyc.63.2.168 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/gerona/52A.2.M117 |2 Crossref |o 10.1093/gerona/52A.2.M117 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ng1847 |2 Crossref |o 10.1038/ng1847 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/gepi.20296 |2 Crossref |o 10.1002/gepi.20296 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.0006-341X.1999.00997.x |2 Crossref |o 10.1111/j.0006-341X.1999.00997.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/1098-2272(200101)20:1<4::AID-GEPI2>3.0.CO;2-T |2 Crossref |o 10.1002/1098-2272(200101)20:1<4::AID-GEPI2>3.0.CO;2-T |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/1098-2272(2000)19:1+<::AID-GEPI6>3.0.CO;2-M |2 Crossref |o 10.1002/1098-2272(2000)19:1+<::AID-GEPI6>3.0.CO;2-M |
| 999 | C | 5 | |y 1995 |2 Crossref |o VJ Vieland 1995 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1534/genetics.104.031039 |2 Crossref |o 10.1534/genetics.104.031039 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1101/gr.4107905 |2 Crossref |o 10.1101/gr.4107905 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.ajhg.2009.11.017 |2 Crossref |o 10.1016/j.ajhg.2009.11.017 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/mp.2012.21 |2 Crossref |o 10.1038/mp.2012.21 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/bioinformatics/btu496 |2 Crossref |o 10.1093/bioinformatics/btu496 |
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