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@ARTICLE{Kadavath:138080,
      author       = {Kadavath, Harindranath and Jaremko, Mariusz and Jaremko,
                      Lukasz and Biernat, Jacek and Mandelkow, Eckhard and
                      Zweckstetter, Markus},
      title        = {{F}olding of the {T}au {P}rotein on {M}icrotubules.},
      journal      = {Angewandte Chemie / International edition},
      volume       = {54},
      number       = {35},
      issn         = {1433-7851},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {DZNE-2020-04402},
      pages        = {10347-10351},
      year         = {2015},
      abstract     = {Microtubules are regulated by microtubule-associated
                      proteins. However, little is known about the structure of
                      microtubule-associated proteins in complex with
                      microtubules. Herein we show that the microtubule-associated
                      protein Tau, which is intrinsically disordered in solution,
                      locally folds into a stable structure upon binding to
                      microtubules. While Tau is highly flexible in solution and
                      adopts a β-sheet structure in amyloid fibrils, in complex
                      with microtubules the conserved hexapeptides at the
                      beginning of the Tau repeats two and three convert into a
                      hairpin conformation. Thus, binding to microtubules
                      stabilizes a unique conformation in Tau.},
      keywords     = {Amyloid: chemistry / Humans / Magnetic Resonance
                      Spectroscopy / Microtubules: chemistry / Protein
                      Conformation / Protein Folding / tau Proteins: chemistry /
                      Amyloid (NLM Chemicals) / tau Proteins (NLM Chemicals)},
      cin          = {AG Zweckstetter / AG Mandelkow 1 ; AG Mandelkow 1},
      ddc          = {540},
      cid          = {I:(DE-2719)1410001 / I:(DE-2719)1013014},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26094605},
      doi          = {10.1002/anie.201501714},
      url          = {https://pub.dzne.de/record/138080},
}