Home > Publications Database > Folding of the Tau Protein on Microtubules. > print

001     138080
005     20240321220351.0
024 7 _ |a 10.1002/anie.201501714
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024 7 _ |a pmid:26094605
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024 7 _ |a 0044-8249
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024 7 _ |a 0570-0833
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024 7 _ |a 1433-7851
|2 ISSN
024 7 _ |a 1521-3757
|2 ISSN
024 7 _ |a 1521-3773
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037 _ _ |a DZNE-2020-04402
041 _ _ |a English
082 _ _ |a 540
100 1 _ |a Kadavath, Harindranath
|0 P:(DE-2719)2811307
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245 _ _ |a Folding of the Tau Protein on Microtubules.
260 _ _ |a Weinheim
|c 2015
|b Wiley-VCH
264 _ 1 |3 online
|2 Crossref
|b Wiley
|c 2015-06-19
264 _ 1 |3 print
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|c 2015-08-24
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Microtubules are regulated by microtubule-associated proteins. However, little is known about the structure of microtubule-associated proteins in complex with microtubules. Herein we show that the microtubule-associated protein Tau, which is intrinsically disordered in solution, locally folds into a stable structure upon binding to microtubules. While Tau is highly flexible in solution and adopts a β-sheet structure in amyloid fibrils, in complex with microtubules the conserved hexapeptides at the beginning of the Tau repeats two and three convert into a hairpin conformation. Thus, binding to microtubules stabilizes a unique conformation in Tau.
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542 _ _ |i 2015-09-01
|2 Crossref
|u http://doi.wiley.com/10.1002/tdm_license_1.1
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Amyloid
|2 NLM Chemicals
650 _ 7 |a tau Proteins
|2 NLM Chemicals
650 _ 2 |a Amyloid: chemistry
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Magnetic Resonance Spectroscopy
|2 MeSH
650 _ 2 |a Microtubules: chemistry
|2 MeSH
650 _ 2 |a Protein Conformation
|2 MeSH
650 _ 2 |a Protein Folding
|2 MeSH
650 _ 2 |a tau Proteins: chemistry
|2 MeSH
700 1 _ |a Jaremko, Mariusz
|0 P:(DE-2719)9000143
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700 1 _ |a Jaremko, Lukasz
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700 1 _ |a Biernat, Jacek
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700 1 _ |a Mandelkow, Eckhard
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700 1 _ |a Zweckstetter, Markus
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773 1 8 |a 10.1002/anie.201501714
|b : Wiley, 2015-06-19
|n 35
|p 10347-10351
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|t Angewandte Chemie International Edition
|v 54
|y 2015
|x 1433-7851
773 _ _ |a 10.1002/anie.201501714
|g Vol. 54, no. 35, p. 10347 - 10351
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856 4 _ |u https://onlinelibrary.wiley.com/doi/10.1002/anie.201501714
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