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@ARTICLE{Klppel:138102,
author = {Klöppel, Stefan and Peter, Jessica and Ludl, Anna and
Pilatus, Anne and Maier, Sabrina and Mader, Irina and
Heimbach, Bernhard and Frings, Lars and Egger, Karl and
Dukart, Juergen and Schroeter, Matthias L and Perneczky,
Robert and Häussermann, Peter and Vach, Werner and Urbach,
Horst and Teipel, Stefan and Hüll, Michael and Abdulkadir,
Ahmed and Initiative, Alzheimer’s Disease Neuroimaging and
Weiner, Michael W and Aisen, Paul and Weiner, Michael and
Aisen, Paul and Petersen, Ronald and Jack, Clifford R and
Jagust, William and Trojanowki, John Q and Toga, Arthur W
and Beckett, Laurel and Green, Robert C and Saykin, Andrew J
and Morris, John and Shaw, Leslie M and Khachaturian, Zaven
and Sorensen, Greg and Carrillo, Maria and Kuller, Lew and
Raichle, Marc and Paul, Steven and Davies, Peter and Fillit,
Howard and Hefti, Franz and Holtzman, Davie and Mesulam, M
Marcel and Potter, William and Snyder, Peter and Schwartz,
Adam and Green, Robert C and Montine, Tom and Petersen,
Ronald and Aisen, Paul and Thomas, Ronald G and Donohue,
Michael and Walter, Sarah and Gessert, Devon and Sather,
Tamie and Jiminez, Gus and Balasubramanian, Archana B and
Mason, Jennifer and Sim, Iris and Beckett, Laurel and
Harvey, Danielle and Donohue, Michael and Jack, Clifford R
and Bernstein, Matthew and Fox, Nick and Thompson, Paul and
Schuff, Norbert and DeCArli, Charles and Borowski, Bret and
Gunter, Jeff and Senjem, Matt and Vemuri, Prashanthi and
Jones, David and Kantarci, Kejal and Ward, Chad and Jagust,
William and Koeppe, Robert A and Foster, Norm and Reiman,
Eric M and Chen, Kewei and Mathis, Chet and Landau, Susan
and Morris, John C and Cairns, Nigel J and Taylor-Reinwald,
Lisa and Shaw, Leslie M and Trojanowki, John Q and Lee,
Virginia and Korecka, Magdalena and Figurski, Michal and
Toga, Arthur W and Crawford, Karen and Neu, Scott and
Saykin, Andrew J and Foroud, Tatiana M and Potkin, Steven
and Shen, Li and Faber, Kelley and Kim, Sungeun and Nho,
Kwangsik and Weiner, Michael W and Thal, Lean and
Khachaturian, Zaven and Thal, Leon and Buckholtz, Neil and
Weiner, Michael W and Snyder, Peter J and Potter, William
and Paul, Steven and Albert, Marylyn and Frank, Richard and
Khachaturian, Zaven and Hsiao, John and Kaye, Jeffrey and
Quinn, Joseph and Silbert, Lisa and Lind, Betty and Carter,
Raina and Dolen, Sara and Schneider, Lon S and Pawluczyk,
Sonia and Beccera, Mauricio and Teodoro, Liberty and Spann,
Bryan M and Brewer, James and Vanderswag, Helen and
Fleisher, Adam and Heidebrink, Judith L and Lord, Joanne L
and Petersen, Ronald and Mason, Sara S and Albers, Colleen S
and Knopman, David and Johnson, Kris and Doody, Rachelle S
and Villanueva-Meyer, Javier and Chowdhury, Munir and
Rountree, Susan and Dang, Mimi and Stern, Yaakov and Honig,
Lawrence S and Bell, Karen L and Ances, Beau and Morris,
John C and Carroll, Maria and Creech, Mary L and Franklin,
Erin and Mintun, Mark A and Schneider, Stacy and Oliver,
Angela and Marson, Daniel and Griffith, Randall and Clark,
David and Geldmacher, David and Brockington, John and
Roberson, Erik and Love, Marissa Natelson and Grossman,
Hillel and Mitsis, Effie and Shah, Raj C and
deToledo-Morrell, Leyla and Duara, Ranjan and Varon, Daniel
and Greig, Maria T and Roberts, Peggy and Albert, Marilyn
and Onyike, Chiadi and D'Agostino, Daniel and Kielb,
Stephanie and Galvin, James E and Cerbone, Brittany and
Michel, Christina A and Pogorelec, Dana M and Rusinek, Henry
and de Leon, Mony J and Glodzik, Lidia and De Santi, Susan
and Doraiswamy, P Murali and Petrella, Jeffrey R and Wong,
Terence Z and Coleman, Edward and Arnold, Steven E and
Karlawish, Jason H and Wolk, David and Clark, Christopher M
and Smith, Charles D and Jicha, Greg and Hardy, Peter and
Sinha, Partha and Oates, Elizabeth and Conrad, Gary and
Lopez, Oscar L and Oakley, MaryAnn and Simpson, Donna M and
Porsteinsson, Anton P and Goldstein, Bonnie S and Martin,
Kim and Makino, Kelly M and Ismail, M Saleem and Brand,
Connie and Mulnard, Ruth A and Thai, Gaby and
Mc-Adams-Ortiz, Catherine and Womack, Kyle and Mathews, Dana
and Quiceno, Mary and Levey, Allan I and Lah, James J and
Cellar, Janet S and Burns, Jeffrey M and Swerdlow, Russell H
and Brooks, William M and Apostolova, Liana and Tingus,
Kathleen and Woo, Ellen and Silverman, Daniel H S and Lu, Po
H and Bartzokis, George and Graff-Radford, Neill R and
Parfitt, Francine and Kendall, Tracy and Johnson, Heather
and Farlow, Martin R and Hake, Ann Marie and Matthews,
Brandy R and Brosch, Jared R and Herring, Scott and Hunt,
Cynthia and van Dyck, Christopher H and Carson, Richard E
and MacAvoy, Martha G and Varma, Pradeep and Chertkow,
Howard and Bergman, Howard and Hosein, Chris and Black,
Sandra and Stefanovic, Bojana and Caldwell, Curtis and
Hsiung, Ging-Yuek Robin and Feldman, Howard and Mudge,
Benita and Assaly, Michele and Finger, Elizabeth and
Pasternack, Stephen and Rachisky, Irina and Trost, Dick and
Kertesz, Andrew and Bernick, Charles and Munic, Donna and
Mesulam, Marek-Marsel and Lipowski, Kristine and Weintraub,
Sandra and Bonakdarpour, Borna and Kerwin, Diana and Wu,
Chuang-Kuo and Johnson, Nancy and Sadowsky, Carl and
Villena, Teresa and Turner, Raymond Scott and Johnson,
Kathleen and Reynolds, Brigid and Sperling, Reisa A and
Johnson, Keith A and Marshall, Gad and Yesavage, Jerome and
Lane, Barton and Rosen, Allyson and Tinklenberg, Jared and
Sabbagh, Marwan N and Belden, Christine M and Jacobson,
Sandra A and Sirrel, Sherye A and Kowall, Neil and Killiany,
Ronald and Budson, Andrew E and Norbash, Alexander and
Johnson, Patricia Lynn and Obisesan, Thomas O and Wolday,
Saba and Allard, Joanne and Lerner, Alan and Ogrocki, Paula
and Tatsuoka, Curtis and Fatica, Parianne and Fletcher, Evan
and Maillard, Pauline and Olichney, John and DeCarli,
Charles and Carmichael, Owen and Kittur, Smita and Borrie,
Michael and Lee, T-Y and Bartha, Rob and Johnson, Sterling
and Asthana, Sanjay and Carlsson, Cynthia M and Potkin,
Steven G and Preda, Adrian and Nguyen, Dana and Tariot,
Pierre and Burke, Anna and Trncic, Nadira and Fleisher, Adam
and Reeder, Stephanie and Bates, Vernice and Capote, Horacio
and Rainka, Michelle and Scharre, Douglas W and Kataki,
Maria and Adeli, Anahita and Zimmerman, Earl A and Celmins,
Dzintra and Brown, Alice D and Neuropsychiatry, Olin and
Pearlson, Godfrey D and Blank, Karen and Anderson, Karen and
Flashman, Laura A and Seltzer, Marc and Hynes, Mary L and
Santulli, Robert B and Sink, Kaycee M and Gordineer, Leslie
and Williamson, Jeff D and Garg, Pradeep and Watkins,
Franklin and Ott, Brian R and Querfurth, Henry and Tremont,
Geoffrey and Salloway, Stephen and Malloy, Paul and Correia,
Stephen and Rosen, Howard J and Miller, Bruce L and Perry,
David and Mintzer, Jacobo and Spicer, Kenneth and Bachman,
David and Finger, Elizabether and Pasternak, Stephen and
Rachinsky, Irina and Rogers, John and Kertesz, Andrew and
Drost, Dick and Pomara, Nunzio and Hernando, Raymundo and
Sarrael, Antero and Schultz, Susan K and Ponto, Laura L
Boles and Shim, Hyungsub and Smith, Karen Ekstam and Relkin,
Norman and Chaing, Gloria and Lin, Michael and Ravdin, Lisa
and Smith, Amanda and Raj, Balebail Ashok and Fargher,
Kristin and Weiner, Michael W and Aisen, Paul and Weiner,
Michael and Aisen, Paul and Petersen, Ronald and Green,
Robert C and Harvey, Danielle and Jack, Clifford R and
Jagust, William and Morris, John C and Saykin, Andrew J and
Shaw, Leslie M and Trojanowki, John Q and Neylan, Thomas and
Grafman, Jordan and Green, Robert C and Montine, Tom and
Weiner, Michael and Petersen, Ronald and Aisen, Paul and
Thomas, Ronald G and Donohue, Michael and Gessert, Devon and
Sather, Tamie and Davis, Melissa and Morrison, Rosemary and
Jiminez, Gus and Neylan, Thomas and Hayes, Jacqueline and
Finley, Shannon and Harvey, Danielle and Donohue, Michael
and Jack, Clifford R and Bernstein, Matthew and Borowski,
Bret and Gunter, Jeff and Senjem, Matt and Kantarci, Kejal
and Jagust, William and Koeppe, Robert A and Foster, Norm
and Reiman, Eric M and Chen, Kewei and Landau, Susan and
Morris, John C and Cairns, Nigel J and Householder, Erin and
Shaw, Leslie M and Trojanowki, John Q and Lee, Virginia and
Korecka, Magdalena and Figurski, Michal and Toga, Arthur W
and Crawford, Karen and Neu, Scott and Saykin, Andrew J and
Foroud, Tatiana M and Potkin, Steven and Shen, Li and Faber,
Kelley and Kim, Sungeun and Nho, Kwangsik and Weiner,
Michael W and Friedl, Karl and Schneider, Lon S and
Pawluczyk, Sonia and Beccera, Mauricio and Brewer, James and
Vanderswag, Helen and Stern, Yaakov and Honig, Lawrence S
and Bell, Karen L and Fleischman, Debra and Arfanakis,
Konstantinos and Shah, Raj C and Duara, Ranjan and Varon,
Daniel and Greig, Maria T and Doraiswamy, P Murali and
Petrella, Jeffrey R and James, Olga and Porsteinsson, Anton
P and Goldstein, Bonnie and Martin, Kimberly S and Mulnard,
Ruth A and Thai, Gaby and McAdams-Ortiz, Catherine and
Mintzer, Jacobo and Massoglia, Dino and Brawman-Mintzer,
Olga and Sadowsky, Carl and Martinez, Walter and Villena,
Teresa and Jagust, William and Landau, Susan and Rosen,
Howard and Perry, David and Turner, Raymond Scott and Behan,
Kelly and Reynolds, Brigid and Sperling, Reisa A and
Johnson, Keith A and Marshall, Gad and Sabbagh, Marwan N and
Jacobson, Sandra A and Sirrel, Sherye A and Obisesan, Thomas
O and Wolday, Saba and Allard, Joanne and Johnson, Sterling
C and Fruehling, J Jay and Harding, Sandra and Peskind,
Elaine R and Petrie, Eric C and Li, Gail and Yesavage,
Jerome A and Taylor, Joy L and Furst, Ansgar J and Chao,
Steven and Relkin, Norman and Chaing, Gloria and Ravdin,
Lisa},
title = {{A}pplying {A}utomated {MR}-{B}ased {D}iagnostic {M}ethods
to the {M}emory {C}linic: {A} {P}rospective {S}tudy.},
journal = {Journal of Alzheimer's disease},
volume = {47},
number = {4},
issn = {1387-2877},
address = {Amsterdam},
publisher = {IOS Press},
reportid = {DZNE-2020-04424},
pages = {939-954},
year = {2015},
abstract = {Several studies have demonstrated that fully automated
pattern recognition methods applied to structural magnetic
resonance imaging (MRI) aid in the diagnosis of dementia,
but these conclusions are based on highly preselected
samples that significantly differ from that seen in a
dementia clinic. At a single dementia clinic, we evaluated
the ability of a linear support vector machine trained with
completely unrelated data to differentiate between
Alzheimer's disease (AD), frontotemporal dementia (FTD),
Lewy body dementia, and healthy aging based on 3D-T1
weighted MRI data sets. Furthermore, we predicted
progression to AD in subjects with mild cognitive impairment
(MCI) at baseline and automatically quantified white matter
hyperintensities from FLAIR-images. Separating additionally
recruited healthy elderly from those with dementia was
accurate with an area under the curve (AUC) of 0.97
(according to Fig. 4). Multi-class separation of patients
with either AD or FTD from other included groups was good on
the training set (AUC > 0.9) but substantially less
accurate (AUC = 0.76 for AD, AUC = 0.78 for FTD) on
134 cases from the local clinic. Longitudinal data from 28
cases with MCI at baseline and appropriate follow-up data
were available. The computer tool discriminated progressive
from stable MCI with AUC = 0.73, compared to
AUC = 0.80 for the training set. A relatively low
accuracy by clinicians (AUC = 0.81) illustrates the
difficulties of predicting conversion in this heterogeneous
cohort. This first application of a MRI-based pattern
recognition method to a routine sample demonstrates
feasibility, but also illustrates that automated multi-class
differential diagnoses have to be the focus of future
methodological developments and application studies.},
keywords = {Aged / Aging: pathology / Alzheimer Disease: diagnosis /
Alzheimer Disease: pathology / Brain: pathology / Diagnosis,
Differential / Disease Progression / Female / Follow-Up
Studies / Frontotemporal Dementia: diagnosis /
Frontotemporal Dementia: pathology / Humans / Imaging,
Three-Dimensional: methods / Lewy Body Disease: diagnosis /
Lewy Body Disease: pathology / Linear Models / Magnetic
Resonance Imaging: methods / Male / Middle Aged /
Prospective Studies / Support Vector Machine / White Matter:
pathology},
cin = {AG Teipel},
ddc = {610},
cid = {I:(DE-2719)1510100},
pnm = {344 - Clinical and Health Care Research (POF3-344)},
pid = {G:(DE-HGF)POF3-344},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:26401773},
pmc = {pmc:PMC4923764},
doi = {10.3233/JAD-150334},
url = {https://pub.dzne.de/record/138102},
}
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