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@ARTICLE{Schurig:138111,
      author       = {Schurig, Katja and Zieris, Andrea and Hermann, Andreas and
                      Freudenberg, Uwe and Heidel, Sabine and Grimmer, Milauscha
                      and Storch, Alexander and Werner, Carsten},
      title        = {{N}eurotropic growth factors and glycosaminoglycan based
                      matrices to induce dopaminergic tissue formation.},
      journal      = {Biomaterials},
      volume       = {67},
      issn         = {0142-9612},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-04433},
      pages        = {205-213},
      year         = {2015},
      abstract     = {Current cell replacement therapies in Parkinson's disease
                      (PD) are limited by low survival of transplanted cell and
                      lacking regeneration of neuronal circuitries. Therefore,
                      bioartificial cell carriers and growth/differentiation
                      factors are applied to improve the integration of
                      transplants and maximize newly generated and/or residual
                      dopaminergic function. In this work, biohybrid poly(ethylene
                      glycol) (starPEG)-heparin hydrogels releasing fibroblast
                      growth factor 2 (FGF-2) and glial-derived neurotrophic
                      factor (GDNF) were used to trigger dopaminergic tissue
                      formation by primary murine midbrain cells in vitro.
                      Matrix-delivered FGF-2 enhanced cell viability while release
                      of GDNF had a pro-neuronal/dopaminergic effect. Combined
                      delivery of both factors from the glycosaminoglycan-based
                      matrices resulted in a tremendous improvement in survival
                      and maturation capacity of dopaminergic neurons as obvious
                      from tyrosine hydroxylase expression and neurite outgrowth.
                      The reported data demonstrate that glycosaminoglycan-based
                      hydrogels can facilitate the administration of neurotrophic
                      factors and are therefore instrumental in potential future
                      treatments of PD.},
      keywords     = {Animals / Cell Differentiation: drug effects / Cell
                      Survival: drug effects / Cells, Cultured / Dopaminergic
                      Neurons: cytology / Dopaminergic Neurons: drug effects /
                      Drug Liberation / Female / Fetus: cytology / Fibroblast
                      Growth Factor 2: pharmacology / Glial Cell Line-Derived
                      Neurotrophic Factor: pharmacology / Glycosaminoglycans:
                      pharmacology / Heparin: chemistry / Hydrogels: chemical
                      synthesis / Mesencephalon: cytology / Mice, Inbred C57BL /
                      Nerve Growth Factors: pharmacology / Neural Stem Cells:
                      cytology / Neural Stem Cells: drug effects / Neurites: drug
                      effects / Neurites: metabolism / Neuroglia: cytology /
                      Neuroglia: drug effects / Polyethylene Glycols: chemical
                      synthesis / Tissue Engineering: methods / Glial Cell
                      Line-Derived Neurotrophic Factor (NLM Chemicals) /
                      Glycosaminoglycans (NLM Chemicals) / Hydrogels (NLM
                      Chemicals) / Nerve Growth Factors (NLM Chemicals) /
                      Fibroblast Growth Factor 2 (NLM Chemicals) / Polyethylene
                      Glycols (NLM Chemicals) / Heparin (NLM Chemicals)},
      cin          = {AG Storch / AG Teipel},
      ddc          = {570},
      cid          = {I:(DE-2719)5000014 / I:(DE-2719)1510100},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26222283},
      doi          = {10.1016/j.biomaterials.2015.07.029},
      url          = {https://pub.dzne.de/record/138111},
}