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024 7 _ |a 10.1136/jnnp-2014-309032.49
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024 7 _ |a 0022-3050
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037 _ _ |a DZNE-2020-04463
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082 _ _ |a 610
100 1 _ |a Ernst, A.
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245 _ _ |a B21 Characterisation Of Mice Overexpressing Mutant Huntingtin Lacking The Spine Morphogenesis Regulator Kalirin-7
260 _ _ |a London
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264 _ 1 |3 online
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264 _ 1 |3 print
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520 _ _ |a The BEMED study (BMJ 2016; 352: DOI 10.1136) was designed as multi-centric, double-blind, plaebo-controlled study in patients with Menière's disease. It should compare a low-level (2 × 24 mg/d) vs. high-level (3 × 48 mg/d) betahstine intake vs. placebo. The primary endpoint was the 'number of vertigo attacks lasting longer than 20 min as documented in a patient's diary'. The main finding of the study was that betahistine did not significantly better reduced the number of vertigo attacks than placebo. Therefore, the BEMED study should be critically discussed in the present paper.
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650 _ 7 |a Betahistine
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650 _ 2 |a Adolescent
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650 _ 2 |a Adult
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650 _ 2 |a Aged
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650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Betahistine: therapeutic use
|2 MeSH
650 _ 2 |a Dose-Response Relationship, Drug
|2 MeSH
650 _ 2 |a Double-Blind Method
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Germany
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Meniere Disease: classification
|2 MeSH
650 _ 2 |a Meniere Disease: diagnosis
|2 MeSH
650 _ 2 |a Meniere Disease: drug therapy
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Young Adult
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700 1 _ |a Schlattmann, P.
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700 1 _ |a Waldfahrer, F.
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700 1 _ |a Westhofen, M.
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773 1 8 |a 10.1136/jnnp-2014-309032.49
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773 _ _ |a 10.1136/jnnp-2014-309032.49
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