TY  - JOUR
AU  - Ewers, Michael
AU  - Mattsson, Niklas
AU  - Minthon, Lennart
AU  - Molinuevo, José L
AU  - Antonell, Anna
AU  - Popp, Julius
AU  - Jessen, Frank
AU  - Herukka, Sanna-Kaisa
AU  - Soininen, Hilka
AU  - Maetzler, Walter
AU  - Leyhe, Thomas
AU  - Bürger, Katharina
AU  - Taniguchi, Miyako
AU  - Urakami, Katsuya
AU  - Lista, Simone
AU  - Dubois, Bruno
AU  - Blennow, Kaj
AU  - Hampel, Harald
TI  - CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study.
JO  - Alzheimer's and dementia
VL  - 11
IS  - 11
SN  - 1552-5260
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DZNE-2020-04552
SP  - 1306-1315
PY  - 2015
AB  - The aim of this study was to test the diagnostic value of cerebrospinal fluid (CSF) beta-amyloid (Aβ1-42), phosphorylated tau, and total tau (tau) to discriminate Alzheimer's disease (AD) dementia from other forms of dementia.A total of 675 CSF samples collected at eight memory clinics were obtained from healthy controls, AD dementia, subjective memory impairment, mild cognitive impairment, vascular dementia, Lewy body dementia (LBD), fronto-temporal dementia (FTD), depression, or other neurological diseases.CSF Aβ1-42 showed the best diagnostic accuracy among the CSF biomarkers. At a sensitivity of 85
KW  - Aged
KW  - Aged, 80 and over
KW  - Alzheimer Disease: cerebrospinal fluid
KW  - Alzheimer Disease: diagnosis
KW  - Amyloid beta-Peptides: cerebrospinal fluid
KW  - Biomarkers: cerebrospinal fluid
KW  - Diagnosis, Differential
KW  - Female
KW  - Humans
KW  - Internationality
KW  - Male
KW  - Middle Aged
KW  - Peptide Fragments: cerebrospinal fluid
KW  - Phosphorylation
KW  - Sensitivity and Specificity
KW  - Spinal Puncture
KW  - tau Proteins: cerebrospinal fluid
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - MAPT protein, human (NLM Chemicals)
KW  - Peptide Fragments (NLM Chemicals)
KW  - amyloid beta-protein (1-42) (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25804998
DO  - DOI:10.1016/j.jalz.2014.12.006
UR  - https://pub.dzne.de/record/138230
ER  -