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| 001 | 138230 | ||
| 005 | 20240321220409.0 | ||
| 024 | 7 | _ | |a 10.1016/j.jalz.2014.12.006 |2 doi |
| 024 | 7 | _ | |a pmid:25804998 |2 pmid |
| 024 | 7 | _ | |a 1552-5260 |2 ISSN |
| 024 | 7 | _ | |a 1552-5279 |2 ISSN |
| 024 | 7 | _ | |a altmetric:3826078 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-04552 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Ewers, Michael |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2015 |b Elsevier |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2015-03-23 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2015-11-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1709030842_12960 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The aim of this study was to test the diagnostic value of cerebrospinal fluid (CSF) beta-amyloid (Aβ1-42), phosphorylated tau, and total tau (tau) to discriminate Alzheimer's disease (AD) dementia from other forms of dementia.A total of 675 CSF samples collected at eight memory clinics were obtained from healthy controls, AD dementia, subjective memory impairment, mild cognitive impairment, vascular dementia, Lewy body dementia (LBD), fronto-temporal dementia (FTD), depression, or other neurological diseases.CSF Aβ1-42 showed the best diagnostic accuracy among the CSF biomarkers. At a sensitivity of 85%, the specificity to differentiate AD dementia against other diagnoses ranged from 42% (for LBD, 95% confidence interval or CI = 32-62) to 77% (for FTD, 95% CI = 62-90).CSF Aβ1-42 discriminates AD dementia from FTD, but shows significant overlap with other non-AD forms of dementia, possibly reflecting the underlying mixed pathologies. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 542 | _ | _ | |i 2015-03-23 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 542 | _ | _ | |i 2015-03-23 |2 Crossref |u http://onlinelibrary.wiley.com/termsAndConditions#vor |
| 542 | _ | _ | |i 2015-03-23 |2 Crossref |u https://www.elsevier.com/tdm/userlicense/1.0/ |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Amyloid beta-Peptides |2 NLM Chemicals |
| 650 | _ | 7 | |a Biomarkers |2 NLM Chemicals |
| 650 | _ | 7 | |a MAPT protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Peptide Fragments |2 NLM Chemicals |
| 650 | _ | 7 | |a amyloid beta-protein (1-42) |2 NLM Chemicals |
| 650 | _ | 7 | |a tau Proteins |2 NLM Chemicals |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Aged, 80 and over |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: diagnosis |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Peptides: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Biomarkers: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Diagnosis, Differential |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Internationality |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Peptide Fragments: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Phosphorylation |2 MeSH |
| 650 | _ | 2 | |a Sensitivity and Specificity |2 MeSH |
| 650 | _ | 2 | |a Spinal Puncture |2 MeSH |
| 650 | _ | 2 | |a tau Proteins: cerebrospinal fluid |2 MeSH |
| 700 | 1 | _ | |a Mattsson, Niklas |b 1 |
| 700 | 1 | _ | |a Minthon, Lennart |b 2 |
| 700 | 1 | _ | |a Molinuevo, José L |b 3 |
| 700 | 1 | _ | |a Antonell, Anna |b 4 |
| 700 | 1 | _ | |a Popp, Julius |b 5 |
| 700 | 1 | _ | |a Jessen, Frank |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Herukka, Sanna-Kaisa |b 7 |
| 700 | 1 | _ | |a Soininen, Hilka |b 8 |
| 700 | 1 | _ | |a Maetzler, Walter |0 P:(DE-2719)2810915 |b 9 |u dzne |
| 700 | 1 | _ | |a Leyhe, Thomas |b 10 |
| 700 | 1 | _ | |a Bürger, Katharina |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Taniguchi, Miyako |b 12 |
| 700 | 1 | _ | |a Urakami, Katsuya |b 13 |
| 700 | 1 | _ | |a Lista, Simone |0 P:(DE-HGF)0 |b 14 |
| 700 | 1 | _ | |a Dubois, Bruno |b 15 |
| 700 | 1 | _ | |a Blennow, Kaj |b 16 |
| 700 | 1 | _ | |a Hampel, Harald |b 17 |
| 773 | 1 | 8 | |a 10.1016/j.jalz.2014.12.006 |b : Wiley, 2015-03-23 |n 11 |p 1306-1315 |3 journal-article |2 Crossref |t Alzheimer's & Dementia |v 11 |y 2015 |x 1552-5260 |
| 773 | _ | _ | |a 10.1016/j.jalz.2014.12.006 |g Vol. 11, no. 11, p. 1306 - 1315 |0 PERI:(DE-600)2201940-6 |n 11 |q 11:11<1306 - 1315 |p 1306-1315 |t Alzheimer's and dementia |v 11 |y 2015 |x 1552-5260 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/138230/files/DZNE-2020-04552_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/138230/files/DZNE-2020-04552_Restricted.pdf?subformat=pdfa |x pdfa |
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| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 9 |6 P:(DE-2719)2810915 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-344 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 0 |
| 914 | 1 | _ | |y 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b ALZHEIMERS DEMENT : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b ALZHEIMERS DEMENT : 2017 |
| 920 | 1 | _ | |0 I:(DE-2719)5000024 |k AG Maetzler |l Functional Neurogeriatrics |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)5000024 |
| 980 | _ | _ | |a UNRESTRICTED |
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