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000138286 0247_ $$2doi$$a10.1084/jem.20150478
000138286 0247_ $$2pmid$$apmid:26458770
000138286 0247_ $$2pmc$$apmc:PMC4612086
000138286 0247_ $$2ISSN$$a0022-1007
000138286 0247_ $$2ISSN$$a1540-9358
000138286 0247_ $$2ISSN$$a1540-9538
000138286 0247_ $$2altmetric$$aaltmetric:4619585
000138286 037__ $$aDZNE-2020-04608
000138286 041__ $$aEnglish
000138286 082__ $$a610
000138286 1001_ $$0P:(DE-2719)2810540$$aVarvel, Nicholas H$$b0$$eFirst author$$udzne
000138286 245__ $$aReplacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease.
000138286 260__ $$aNew York, NY$$bRockefeller Univ. Press$$c2015
000138286 264_1 $$2Crossref$$3online$$bRockefeller University Press$$c2015-10-12
000138286 264_1 $$2Crossref$$3print$$bRockefeller University Press$$c2015-10-19
000138286 3367_ $$2DRIVER$$aarticle
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000138286 3367_ $$2BibTeX$$aARTICLE
000138286 3367_ $$2ORCID$$aJOURNAL_ARTICLE
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000138286 520__ $$aImmune cells of myeloid lineage are encountered in the Alzheimer's disease (AD) brain, where they cluster around amyloid-β plaques. However, assigning functional roles to myeloid cell subtypes has been problematic, and the potential for peripheral myeloid cells to alleviate AD pathology remains unclear. Therefore, we asked whether replacement of brain-resident myeloid cells with peripheral monocytes alters amyloid deposition in two mouse models of cerebral β-amyloidosis (APP23 and APPPS1). Interestingly, early after repopulation, infiltrating monocytes neither clustered around plaques nor showed Trem2 expression. However, with increasing time in the brain, infiltrating monocytes became plaque associated and also Trem2 positive. Strikingly, however, monocyte repopulation for up to 6 mo did not modify amyloid load in either model, independent of the stage of pathology at the time of repopulation. Our results argue against a long-term role of peripheral monocytes that is sufficiently distinct from microglial function to modify cerebral β-amyloidosis. Therefore, myeloid replacement by itself is not likely to be effective as a therapeutic approach for AD.
000138286 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000138286 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000138286 650_7 $$2NLM Chemicals$$aMembrane Glycoproteins
000138286 650_7 $$2NLM Chemicals$$aReceptors, Immunologic
000138286 650_7 $$2NLM Chemicals$$aTrem2 protein, mouse
000138286 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000138286 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000138286 650_2 $$2MeSH$$aAlzheimer Disease: therapy
000138286 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000138286 650_2 $$2MeSH$$aAnimals
000138286 650_2 $$2MeSH$$aBrain: metabolism
000138286 650_2 $$2MeSH$$aBrain: pathology
000138286 650_2 $$2MeSH$$aDisease Models, Animal
000138286 650_2 $$2MeSH$$aFemale
000138286 650_2 $$2MeSH$$aMale
000138286 650_2 $$2MeSH$$aMembrane Glycoproteins: analysis
000138286 650_2 $$2MeSH$$aMice
000138286 650_2 $$2MeSH$$aMice, Inbred C57BL
000138286 650_2 $$2MeSH$$aMonocytes: physiology
000138286 650_2 $$2MeSH$$aMyeloid Cells: physiology
000138286 650_2 $$2MeSH$$aReceptors, Immunologic: analysis
000138286 7001_ $$0P:(DE-HGF)0$$aGrathwohl, Stefan A$$b1
000138286 7001_ $$0P:(DE-2719)2810939$$aDegenhardt, Karoline$$b2$$udzne
000138286 7001_ $$0P:(DE-2719)9000263$$aResch, Claudia$$b3$$udzne
000138286 7001_ $$0P:(DE-2719)2380523$$aBosch, Andrea$$b4$$udzne
000138286 7001_ $$0P:(DE-2719)2000010$$aJucker, Mathias$$b5$$udzne
000138286 7001_ $$0P:(DE-2719)2811021$$aNeher, Jonas J$$b6$$eLast author$$udzne
000138286 77318 $$2Crossref$$3journal-article$$a10.1084/jem.20150478$$b : Rockefeller University Press, 2015-10-12$$n11$$p1803-1809$$tJournal of Experimental Medicine$$v212$$x1540-9538$$y2015
000138286 773__ $$0PERI:(DE-600)1477240-1$$a10.1084/jem.20150478$$gVol. 212, no. 11, p. 1803 - 1809$$n11$$p1803-1809$$q212:11<1803 - 1809$$tJournal of experimental medicine$$v212$$x1540-9538$$y2015
000138286 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612086
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000138286 9141_ $$y2015
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000138286 9201_ $$0I:(DE-2719)1210001$$kAG Jucker$$lCell Biology of Neurologic Diseases$$x0
000138286 9201_ $$0I:(DE-2719)1210012$$kAG Neher$$lExperimental neuroimmunology$$x1
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