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000138297 0247_ $$2ISSN$$a1097-6256
000138297 0247_ $$2ISSN$$a1471-003X
000138297 0247_ $$2ISSN$$a1471-0048
000138297 0247_ $$2ISSN$$a1546-1726
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000138297 037__ $$aDZNE-2020-04619
000138297 041__ $$aEnglish
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000138297 1001_ $$0P:(DE-2719)2810512$$aHalder, Rashi$$b0$$eFirst author
000138297 245__ $$aDNA methylation changes in plasticity genes accompany the formation and maintenance of memory.
000138297 260__ $$aLondon$$bNature Publ. Group58142$$c2016
000138297 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2015-12-14
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000138297 520__ $$aThe ability to form memories is a prerequisite for an organism's behavioral adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. In an effort to unravel the epigenetic network underlying both short- and long-term memory, we examined chromatin modification changes in two distinct mouse brain regions, two cell types and three time points before and after contextual learning. We found that histone modifications predominantly changed during memory acquisition and correlated surprisingly little with changes in gene expression. Although long-lasting changes were almost exclusive to neurons, learning-related histone modification and DNA methylation changes also occurred in non-neuronal cell types, suggesting a functional role for non-neuronal cells in epigenetic learning. Finally, our data provide evidence for a molecular framework of memory acquisition and maintenance, wherein DNA methylation could alter the expression and splicing of genes involved in functional plasticity and synaptic wiring.
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000138297 542__ $$2Crossref$$i2015-12-14$$uhttp://www.springer.com/tdm
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000138297 650_7 $$2NLM Chemicals$$aChromatin
000138297 650_7 $$2NLM Chemicals$$aHistones
000138297 650_2 $$2MeSH$$aAnimals
000138297 650_2 $$2MeSH$$aBehavior, Animal: physiology
000138297 650_2 $$2MeSH$$aCA1 Region, Hippocampal: metabolism
000138297 650_2 $$2MeSH$$aChromatin: chemistry
000138297 650_2 $$2MeSH$$aConditioning, Psychological
000138297 650_2 $$2MeSH$$aDNA Methylation: genetics
000138297 650_2 $$2MeSH$$aDNA Methylation: physiology
000138297 650_2 $$2MeSH$$aEpigenesis, Genetic: genetics
000138297 650_2 $$2MeSH$$aEpigenesis, Genetic: physiology
000138297 650_2 $$2MeSH$$aFear
000138297 650_2 $$2MeSH$$aGene Expression: genetics
000138297 650_2 $$2MeSH$$aGene Expression: physiology
000138297 650_2 $$2MeSH$$aGyrus Cinguli: metabolism
000138297 650_2 $$2MeSH$$aHistones: metabolism
000138297 650_2 $$2MeSH$$aMale
000138297 650_2 $$2MeSH$$aMemory, Long-Term: physiology
000138297 650_2 $$2MeSH$$aMemory, Short-Term: physiology
000138297 650_2 $$2MeSH$$aMice
000138297 650_2 $$2MeSH$$aMice, Inbred C57BL
000138297 650_2 $$2MeSH$$aNeuronal Plasticity: genetics
000138297 650_2 $$2MeSH$$aNeuronal Plasticity: physiology
000138297 7001_ $$0P:(DE-2719)2810666$$aHennion, Magali$$b1
000138297 7001_ $$0P:(DE-2719)9000325$$aVidal, Ramon O$$b2
000138297 7001_ $$0P:(DE-2719)2810755$$aShomroni, Orr$$b3
000138297 7001_ $$0P:(DE-2719)2811127$$aRahman, Raza-Ur$$b4
000138297 7001_ $$0P:(DE-2719)2811012$$aRajput, Ashish$$b5
000138297 7001_ $$0P:(DE-2719)2811063$$aPena Centeno, Tonatiuh$$b6$$udzne
000138297 7001_ $$0P:(DE-2719)9000319$$avan Bebber, Frauke$$b7
000138297 7001_ $$0P:(DE-2719)2810626$$aCapece, Vincenzo$$b8
000138297 7001_ $$0P:(DE-2719)2810949$$aGarcia Vizcaino, Julio C$$b9
000138297 7001_ $$0P:(DE-2719)2810585$$aSchütz, Anna-Lena$$b10
000138297 7001_ $$0P:(DE-2719)2810773$$aBurkhardt, Susanne$$b11
000138297 7001_ $$0P:(DE-2719)2810482$$aBenito, Eva$$b12
000138297 7001_ $$0P:(DE-2719)9000229$$aNavarro-Sala, Magdalena$$b13
000138297 7001_ $$0P:(DE-2719)9000144$$aJavan, Sanaz Bahari$$b14
000138297 7001_ $$0P:(DE-2719)2202037$$aHaass, Christian$$b15
000138297 7001_ $$0P:(DE-2719)2241638$$aSchmid, Bettina$$b16
000138297 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b17$$eCorresponding author
000138297 7001_ $$0P:(DE-2719)2810547$$aBonn, Stefan$$b18$$eLast author
000138297 77318 $$2Crossref$$3journal-article$$a10.1038/nn.4194$$b : Springer Science and Business Media LLC, 2015-12-14$$n1$$p102-110$$tNature Neuroscience$$v19$$x1097-6256$$y2015
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