TY  - JOUR
AU  - Halder, Rashi
AU  - Hennion, Magali
AU  - Vidal, Ramon O
AU  - Shomroni, Orr
AU  - Rahman, Raza-Ur
AU  - Rajput, Ashish
AU  - Pena Centeno, Tonatiuh
AU  - van Bebber, Frauke
AU  - Capece, Vincenzo
AU  - Garcia Vizcaino, Julio C
AU  - Schütz, Anna-Lena
AU  - Burkhardt, Susanne
AU  - Benito, Eva
AU  - Navarro-Sala, Magdalena
AU  - Javan, Sanaz Bahari
AU  - Haass, Christian
AU  - Schmid, Bettina
AU  - Fischer, Andre
AU  - Bonn, Stefan
TI  - DNA methylation changes in plasticity genes accompany the formation and maintenance of memory.
JO  - Nature reviews / Neuroscience
VL  - 19
IS  - 1
SN  - 1097-6256
CY  - London
PB  - Nature Publ. Group58142
M1  - DZNE-2020-04619
SP  - 102-110
PY  - 2016
AB  - The ability to form memories is a prerequisite for an organism's behavioral adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. In an effort to unravel the epigenetic network underlying both short- and long-term memory, we examined chromatin modification changes in two distinct mouse brain regions, two cell types and three time points before and after contextual learning. We found that histone modifications predominantly changed during memory acquisition and correlated surprisingly little with changes in gene expression. Although long-lasting changes were almost exclusive to neurons, learning-related histone modification and DNA methylation changes also occurred in non-neuronal cell types, suggesting a functional role for non-neuronal cells in epigenetic learning. Finally, our data provide evidence for a molecular framework of memory acquisition and maintenance, wherein DNA methylation could alter the expression and splicing of genes involved in functional plasticity and synaptic wiring.
KW  - Animals
KW  - Behavior, Animal: physiology
KW  - CA1 Region, Hippocampal: metabolism
KW  - Chromatin: chemistry
KW  - Conditioning, Psychological
KW  - DNA Methylation: genetics
KW  - DNA Methylation: physiology
KW  - Epigenesis, Genetic: genetics
KW  - Epigenesis, Genetic: physiology
KW  - Fear
KW  - Gene Expression: genetics
KW  - Gene Expression: physiology
KW  - Gyrus Cinguli: metabolism
KW  - Histones: metabolism
KW  - Male
KW  - Memory, Long-Term: physiology
KW  - Memory, Short-Term: physiology
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Neuronal Plasticity: genetics
KW  - Neuronal Plasticity: physiology
KW  - Chromatin (NLM Chemicals)
KW  - Histones (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26656643
DO  - DOI:10.1038/nn.4194
UR  - https://pub.dzne.de/record/138297
ER  -