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@ARTICLE{Halder:138297,
      author       = {Halder, Rashi and Hennion, Magali and Vidal, Ramon O and
                      Shomroni, Orr and Rahman, Raza-Ur and Rajput, Ashish and
                      Pena Centeno, Tonatiuh and van Bebber, Frauke and Capece,
                      Vincenzo and Garcia Vizcaino, Julio C and Schütz, Anna-Lena
                      and Burkhardt, Susanne and Benito, Eva and Navarro-Sala,
                      Magdalena and Javan, Sanaz Bahari and Haass, Christian and
                      Schmid, Bettina and Fischer, Andre and Bonn, Stefan},
      title        = {{DNA} methylation changes in plasticity genes accompany the
                      formation and maintenance of memory.},
      journal      = {Nature reviews / Neuroscience},
      volume       = {19},
      number       = {1},
      issn         = {1097-6256},
      address      = {London},
      publisher    = {Nature Publ. Group58142},
      reportid     = {DZNE-2020-04619},
      pages        = {102-110},
      year         = {2016},
      abstract     = {The ability to form memories is a prerequisite for an
                      organism's behavioral adaptation to environmental changes.
                      At the molecular level, the acquisition and maintenance of
                      memory requires changes in chromatin modifications. In an
                      effort to unravel the epigenetic network underlying both
                      short- and long-term memory, we examined chromatin
                      modification changes in two distinct mouse brain regions,
                      two cell types and three time points before and after
                      contextual learning. We found that histone modifications
                      predominantly changed during memory acquisition and
                      correlated surprisingly little with changes in gene
                      expression. Although long-lasting changes were almost
                      exclusive to neurons, learning-related histone modification
                      and DNA methylation changes also occurred in non-neuronal
                      cell types, suggesting a functional role for non-neuronal
                      cells in epigenetic learning. Finally, our data provide
                      evidence for a molecular framework of memory acquisition and
                      maintenance, wherein DNA methylation could alter the
                      expression and splicing of genes involved in functional
                      plasticity and synaptic wiring.},
      keywords     = {Animals / Behavior, Animal: physiology / CA1 Region,
                      Hippocampal: metabolism / Chromatin: chemistry /
                      Conditioning, Psychological / DNA Methylation: genetics /
                      DNA Methylation: physiology / Epigenesis, Genetic: genetics
                      / Epigenesis, Genetic: physiology / Fear / Gene Expression:
                      genetics / Gene Expression: physiology / Gyrus Cinguli:
                      metabolism / Histones: metabolism / Male / Memory,
                      Long-Term: physiology / Memory, Short-Term: physiology /
                      Mice / Mice, Inbred C57BL / Neuronal Plasticity: genetics /
                      Neuronal Plasticity: physiology / Chromatin (NLM Chemicals)
                      / Histones (NLM Chemicals)},
      cin          = {AG Fischer / AG Brömer 1 / AG Bonn 1 / Göttingen common /
                      AG Schmid / AG Bonn 2 / AG Haass},
      ddc          = {570},
      cid          = {I:(DE-2719)1410002 / I:(DE-2719)5000021 /
                      I:(DE-2719)1410003 / I:(DE-2719)6000014 / I:(DE-2719)1140002
                      / I:(DE-2719)1440012 / I:(DE-2719)1110007},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26656643},
      doi          = {10.1038/nn.4194},
      url          = {https://pub.dzne.de/record/138297},
}