Home > Publications Database > On the Recombination Rate Estimation in the Presence of Population Substructure. > print

001     138304
005     20240321220417.0
024 7 _ |a 10.1371/journal.pone.0145152
|2 doi
024 7 _ |a pmid:26716445
|2 pmid
024 7 _ |a pmc:PMC4696844
|2 pmc
037 _ _ |a DZNE-2020-04626
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Hecker, Julian
|b 0
245 _ _ |a On the Recombination Rate Estimation in the Presence of Population Substructure.
260 _ _ |a San Francisco, California, US
|c 2015
|b PLOS
264 _ 1 |3 online
|2 Crossref
|b Public Library of Science (PLoS)
|c 2015-12-30
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1604651402_15307
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a As recombination events are not uniformly distributed along the human genome, the estimation of fine-scale recombination maps, e.g. HapMap Project, has been one of the major research endeavors over the last couple of years. For simulation studies, these estimates provide realistic reference scenarios to design future study and to develop novel methodology. To achieve a feasible framework for the estimation of such recombination maps, existing methodology uses sample probabilities for a two-locus model with recombination, with recent advances allowing for computationally fast implementations. In this work, we extend the existing theoretical framework for the recombination rate estimation to the presence of population substructure. We show under which assumptions the existing methodology can still be applied. We illustrate our extension of the methodology by an extensive simulation study.
536 _ _ |a 345 - Population Studies and Genetics (POF3-345)
|0 G:(DE-HGF)POF3-345
|c POF3-345
|f POF III
|x 0
542 _ _ |i 2015-12-30
|2 Crossref
|u http://creativecommons.org/licenses/by/4.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 2 |a Computer Simulation
|2 MeSH
650 _ 2 |a Genetics, Population: methods
|2 MeSH
650 _ 2 |a Genome, Human: genetics
|2 MeSH
650 _ 2 |a HapMap Project
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Models, Genetic
|2 MeSH
650 _ 2 |a Recombination, Genetic: genetics
|2 MeSH
650 _ 2 |a Regression Analysis
|2 MeSH
700 1 _ |a Prokopenko, Dmitry
|b 1
700 1 _ |a Lange, Christoph
|0 P:(DE-2719)9000181
|b 2
|u dzne
700 1 _ |a Fier, Heide Löhlein
|b 3
773 1 8 |a 10.1371/journal.pone.0145152
|b : Public Library of Science (PLoS), 2015-12-30
|n 12
|p e0145152
|3 journal-article
|2 Crossref
|t PLOS ONE
|v 10
|y 2015
|x 1932-6203
773 _ _ |a 10.1371/journal.pone.0145152
|g Vol. 10, no. 12, p. e0145152 -
|0 PERI:(DE-600)2267670-3
|n 12
|q 10:12|p e0145152
|t PLOS ONE
|v 10
|y 2015
|x 1932-6203
856 4 _ |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145152
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696844
856 4 _ |u https://pub.dzne.de/record/138304/files/4266.PDF
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/138304/files/4266.gif?subformat=icon
|x icon
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/138304/files/4266.jpg?subformat=icon-1440
|x icon-1440
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/138304/files/4266.jpg?subformat=icon-180
|x icon-180
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/138304/files/4266.jpg?subformat=icon-640
|x icon-640
|y OpenAccess
909 C O |o oai:pub.dzne.de:138304
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 2
|6 P:(DE-2719)9000181
913 1 _ |a DE-HGF
|b Forschungsbereich Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-345
|2 G:(DE-HGF)POF3-300
|v Population Studies and Genetics
|x 0
914 1 _ |y 2015
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a Creative Commons Attribution CC BY (No Version)
|0 LIC:(DE-HGF)CCBYNV
|2 V:(DE-HGF)
|b DOAJ
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1040
|2 StatID
|b Zoological Record
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b PLOS ONE : 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
920 1 _ |0 I:(DE-2719)7000008
|k U T4 Researchers - Bonn
|l U T4 Researchers - Bonn
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)7000008
980 1 _ |a FullTexts
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nrg1346
|2 Crossref
|o 10.1038/nrg1346
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nature09298
|2 Crossref
|o 10.1038/nature09298
999 C 5 |9 -- missing cx lookup --
|a 10.1038/ng1565
|2 Crossref
|o 10.1038/ng1565
999 C 5 |9 -- missing cx lookup --
|a 10.1101/gr.3709305
|2 Crossref
|o 10.1101/gr.3709305
999 C 5 |9 -- missing cx lookup --
|a 10.1126/science.1092500
|2 Crossref
|o 10.1126/science.1092500
999 C 5 |9 -- missing cx lookup --
|a 10.1101/gr.6386707
|2 Crossref
|o 10.1101/gr.6386707
999 C 5 |y 2001
|2 Crossref
|o RR Hudson 2001
999 C 5 |y 2001
|2 Crossref
|o P Fearnhead 2001
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nature11632
|2 Crossref
|o 10.1038/nature11632
999 C 5 |2 Crossref
|o
999 C 5 |9 -- missing cx lookup --
|a 10.1038/ng917
|2 Crossref
|o 10.1038/ng917
999 C 5 |9 -- missing cx lookup --
|a 10.1214/09-AAP646
|2 Crossref
|o 10.1214/09-AAP646
999 C 5 |9 -- missing cx lookup --
|a 10.1534/genetics.109.107995
|2 Crossref
|o 10.1534/genetics.109.107995
999 C 5 |9 -- missing cx lookup --
|a 10.1214/11-AAP780
|2 Crossref
|o 10.1214/11-AAP780
999 C 5 |9 -- missing cx lookup --
|a 10.1007/BF00276078
|2 Crossref
|o 10.1007/BF00276078
999 C 5 |9 -- missing cx lookup --
|a 10.1007/BF00275916
|2 Crossref
|o 10.1007/BF00275916
999 C 5 |y 2004
|2 Crossref
|o WJ Ewens 2004
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s002850100104
|2 Crossref
|o 10.1007/s002850100104
999 C 5 |9 -- missing cx lookup --
|a 10.1016/0040-5809(83)90029-1
|2 Crossref
|o 10.1016/0040-5809(83)90029-1
999 C 5 |y 1998
|2 Crossref
|o T Nagylaki 1998
999 C 5 |y 1997
|2 Crossref
|o M Nordborg 1997
999 C 5 |y 1993
|2 Crossref
|o M Notohara 1993
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s002850050097
|2 Crossref
|o 10.1007/s002850050097
999 C 5 |9 -- missing cx lookup --
|a 10.1017/S002190020001531X
|2 Crossref
|o 10.1017/S002190020001531X
999 C 5 |y 2005
|2 Crossref
|o SN Ethier 2005
999 C 5 |9 -- missing cx lookup --
|a 10.1017/S0001867800023120
|2 Crossref
|o 10.1017/S0001867800023120

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21