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@ARTICLE{Ambadipudi:138314,
      author       = {Ambadipudi, Susmitha and Zweckstetter, Markus},
      title        = {{T}argeting intrinsically disordered proteins in rational
                      drug discovery.},
      journal      = {Expert opinion on drug discovery},
      volume       = {11},
      number       = {1},
      issn         = {1746-0441},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {DZNE-2020-04636},
      pages        = {65-77},
      year         = {2016},
      abstract     = {Intrinsically disordered proteins (IDPs) and intrinsically
                      disordered protein regions (IDPRs) have gained wide
                      recognition over the past decade due to their versatile
                      roles in cell physiology and pathology. A large repertoire
                      of IDPs/IDPRs has been implicated in numerous diseases,
                      making them potential targets for therapeutic intervention.
                      Recent advances in experimental methods and computational
                      approaches have enabled detection and characterization of
                      these highly dynamic proteins at atomistic detail, thus
                      facilitating disorder/dynamic-based drug discovery.This
                      article presents an overview of the functional relevance and
                      pathological implications of IDPs/IDPRs in cells. The
                      authors outline the currently available experimental methods
                      employed for structural characterization of these proteins.
                      They also exemplify the practical limitations encountered
                      during such characterization and ways to overcome them.
                      Taken together, the article discusses the plausibility of
                      exploiting protein disorder for drug
                      targeting.Disorder-based drug targeting is gearing up in the
                      realm of novel drug discovery approaches. Tools for probing
                      the molecular features of IDPs and IDPRs are rapidly
                      improving and start to provide accurate descriptions of the
                      complex ensembles populated by IDPs/IDPRs. They thus pave
                      the way for the development of drug molecules, which
                      specifically target disease-associated disorder.},
      subtyp        = {Review Article},
      keywords     = {Animals / Drug Design / Drug Discovery: methods / Humans /
                      Intrinsically Disordered Proteins: metabolism / Models,
                      Molecular / Molecular Targeted Therapy / Protein
                      Conformation / Intrinsically Disordered Proteins (NLM
                      Chemicals)},
      cin          = {AG Zweckstetter},
      ddc          = {610},
      cid          = {I:(DE-2719)1410001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26549326},
      doi          = {10.1517/17460441.2016.1107041},
      url          = {https://pub.dzne.de/record/138314},
}