TY  - JOUR
AU  - Lundt, Andreas
AU  - Wormuth, Carola
AU  - Siwek, Magdalena Elisabeth
AU  - Müller, Ralf
AU  - Ehninger, Dan
AU  - Henseler, Christina
AU  - Broich, Karl
AU  - Papazoglou, Anna
AU  - Weiergräber, Marco
TI  - EEG Radiotelemetry in Small Laboratory Rodents: A Powerful State-of-the Art Approach in Neuropsychiatric, Neurodegenerative, and Epilepsy Research.
JO  - Neural plasticity
VL  - 2016
SN  - 2090-5904
CY  - New York, NY
PB  - Hindawi
M1  - DZNE-2020-04638
SP  - 8213878 
PY  - 2016
AB  - EEG radiotelemetry plays an important role in the neurological characterization of transgenic mouse models of neuropsychiatric and neurodegenerative diseases as well as epilepsies providing valuable insights into underlying pathophysiological mechanisms and thereby facilitating the development of new translational approaches. We elaborate on the major advantages of nonrestraining EEG radiotelemetry in contrast to restraining procedures such as tethered systems or jacket systems containing recorders. Whereas a main disadvantage of the latter is their unphysiological, restraining character, telemetric EEG recording overcomes these disadvantages. It allows precise and highly sensitive measurement under various physiological and pathophysiological conditions. Here we present a detailed description of a straightforward successful, quick, and efficient technique for intraperitoneal as well as subcutaneous pouch implantation of a standard radiofrequency transmitter in mice and rats. We further present computerized 3D-stereotaxic placement of both epidural and deep intracerebral electrodes. Preoperative preparation of mice and rats, suitable anaesthesia, and postoperative treatment and pain management are described in detail. A special focus is on fields of application, technical and experimental pitfalls, and technical connections of commercially available radiotelemetry systems with other electrophysiological setups.
KW  - Animals
KW  - Brain: physiopathology
KW  - Disease Models, Animal
KW  - Electroencephalography: methods
KW  - Epilepsy: physiopathology
KW  - Mental Disorders: physiopathology
KW  - Mice
KW  - Neurodegenerative Diseases: physiopathology
KW  - Rats
KW  - Research
KW  - Telemetry: methods
LB  - PUB:(DE-HGF)16
C6  - pmid:26819775
C2  - pmc:PMC4706962
DO  - DOI:10.1155/2016/8213878
UR  - https://pub.dzne.de/record/138316
ER  -