TY  - JOUR
AU  - Elshehabi, Morad
AU  - Maier, Katrin S
AU  - Hasmann, Sandra E
AU  - Nussbaum, Susanne
AU  - Herbst, Heinz
AU  - Heger, Tanja
AU  - Berg, Daniela
AU  - Hobert, Markus A
AU  - Maetzler, Walter
TI  - Limited Effect of Dopaminergic Medication on Straight Walking and Turning in Early-to-Moderate Parkinson's Disease during Single and Dual Tasking.
JO  - Frontiers in aging neuroscience
VL  - 8
SN  - 1663-4365
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - DZNE-2020-04672
SP  - 4
PY  - 2016
AB  - In Parkinson's disease (PD), the effects of dopaminergic medication on straight walking and turning were mainly investigated under single tasking (ST) conditions. However, multitasking situations are considered more daily relevant.Thirty-nine early-to-moderate PD patients performed the following standardized ST and dual tasks as fast as possible for 1 min during On- and Off-medication while wearing inertial sensors: straight walking and turning, checking boxes, and subtracting serial 7s. Quantitative gait parameters as well as velocity of the secondary tasks were analyzed.The following parameters improved significantly in On-medication during ST: gait velocity during straight walking (p = 0.03); step duration (p = 0.048) and peak velocity (p = 0.04) during turning; velocity of checking boxes during ST (p = 0.04) and DT (p = 0.04). Velocity of checking boxes was the only parameter that also improved during DT.These results suggest that dopaminergic medication does not relevantly influence straight walking and turning in early-to-moderate PD during DT.
LB  - PUB:(DE-HGF)16
C6  - pmid:26858638
C2  - pmc:PMC4728201
DO  - DOI:10.3389/fnagi.2016.00004
UR  - https://pub.dzne.de/record/138350
ER  -