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@ARTICLE{Reber:138364,
author = {Reber, T. P. and Do Lam, A. T. A. and Axmacher, N. and
Elger, C. E. and Helmstaedter, C. and Henke, K. and Fell,
J.},
title = {{I}ntracranial {EEG} correlates of implicit relational
inference within the hippocampus.},
journal = {Hippocampus},
volume = {26},
number = {1},
issn = {1050-9631},
address = {New York, NY [u.a.]},
publisher = {Wiley},
reportid = {DZNE-2020-04686},
pages = {54-66},
year = {2016},
abstract = {Drawing inferences from past experiences enables adaptive
behavior in future situations. Inference has been shown to
depend on hippocampal processes. Usually, inference is
considered a deliberate and effortful mental act which
happens during retrieval, and requires the focus of our
awareness. Recent fMRI studies hint at the possibility that
some forms of hippocampus-dependent inference can also occur
during encoding and possibly also outside of awareness.
Here, we sought to further explore the feasibility of
hippocampal implicit inference, and specifically address the
temporal evolution of implicit inference using intracranial
EEG. Presurgical epilepsy patients with hippocampal depth
electrodes viewed a sequence of word pairs, and judged the
semantic fit between two words in each pair. Some of the
word pairs entailed a common word (e.g., 'winter-red,'
'red-cat') such that an indirect relation was established in
following word pairs (e.g., 'winter-cat'). The behavioral
results suggested that drawing inference implicitly from
past experience is feasible because indirect relations
seemed to foster 'fit' judgments while the absence of
indirect relations fostered 'do not fit' judgments, even
though the participants were unaware of the indirect
relations. A event-related potential (ERP) difference
emerging 400 ms post-stimulus was evident in the hippocampus
during encoding, suggesting that indirect relations were
already established automatically during encoding of the
overlapping word pairs. Further ERP differences emerged
later post-stimulus (1,500 ms), were modulated by the
participants' responses and were evident during encoding and
test. Furthermore, response-locked ERP effects were evident
at test. These ERP effects could hence be a correlate of the
interaction of implicit memory with decision-making.
Together, the data map out a time-course in which the
hippocampus automatically integrates memories from discrete
but related episodes to implicitly influence future decision
making.},
keywords = {Adult / Decision Making: physiology / Drug Resistant
Epilepsy: physiopathology / Drug Resistant Epilepsy:
psychology / Drug Resistant Epilepsy: surgery /
Electrocorticography / Epilepsy, Temporal Lobe:
physiopathology / Epilepsy, Temporal Lobe: psychology /
Epilepsy, Temporal Lobe: surgery / Evoked Potentials /
Female / Hippocampus: physiology / Hippocampus:
physiopathology / Hippocampus: surgery / Humans / Judgment:
physiology / Language Tests / Male / Memory: physiology /
Middle Aged / Neuropsychological Tests / Photic Stimulation
/ Reaction Time / Reading / Semantics / Visual Perception:
physiology / Young Adult},
cin = {AG Axmacher},
ddc = {610},
cid = {I:(DE-2719)5000027},
pnm = {344 - Clinical and Health Care Research (POF3-344)},
pid = {G:(DE-HGF)POF3-344},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:26136107},
doi = {10.1002/hipo.22490},
url = {https://pub.dzne.de/record/138364},
}