Home > Publications Database > Intracranial EEG correlates of implicit relational inference within the hippocampus. > print

001     138364
005     20240321220424.0
024 7 _ |a 10.1002/hipo.22490
|2 doi
024 7 _ |a pmid:26136107
|2 pmid
024 7 _ |a 1050-9631
|2 ISSN
024 7 _ |a 1098-1063
|2 ISSN
024 7 _ |a altmetric:4235289
|2 altmetric
037 _ _ |a DZNE-2020-04686
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Reber, T. P.
|0 P:(DE-HGF)0
|b 0
|e Corresponding author
245 _ _ |a Intracranial EEG correlates of implicit relational inference within the hippocampus.
260 _ _ |a New York, NY [u.a.]
|c 2016
|b Wiley
264 _ 1 |3 online
|2 Crossref
|b Wiley
|c 2015-07-24
264 _ 1 |3 print
|2 Crossref
|b Wiley
|c 2016-01-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1589543728_30864
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Drawing inferences from past experiences enables adaptive behavior in future situations. Inference has been shown to depend on hippocampal processes. Usually, inference is considered a deliberate and effortful mental act which happens during retrieval, and requires the focus of our awareness. Recent fMRI studies hint at the possibility that some forms of hippocampus-dependent inference can also occur during encoding and possibly also outside of awareness. Here, we sought to further explore the feasibility of hippocampal implicit inference, and specifically address the temporal evolution of implicit inference using intracranial EEG. Presurgical epilepsy patients with hippocampal depth electrodes viewed a sequence of word pairs, and judged the semantic fit between two words in each pair. Some of the word pairs entailed a common word (e.g., 'winter-red,' 'red-cat') such that an indirect relation was established in following word pairs (e.g., 'winter-cat'). The behavioral results suggested that drawing inference implicitly from past experience is feasible because indirect relations seemed to foster 'fit' judgments while the absence of indirect relations fostered 'do not fit' judgments, even though the participants were unaware of the indirect relations. A event-related potential (ERP) difference emerging 400 ms post-stimulus was evident in the hippocampus during encoding, suggesting that indirect relations were already established automatically during encoding of the overlapping word pairs. Further ERP differences emerged later post-stimulus (1,500 ms), were modulated by the participants' responses and were evident during encoding and test. Furthermore, response-locked ERP effects were evident at test. These ERP effects could hence be a correlate of the interaction of implicit memory with decision-making. Together, the data map out a time-course in which the hippocampus automatically integrates memories from discrete but related episodes to implicitly influence future decision making.
536 _ _ |a 344 - Clinical and Health Care Research (POF3-344)
|0 G:(DE-HGF)POF3-344
|c POF3-344
|f POF III
|x 0
542 _ _ |i 2015-09-01
|2 Crossref
|u http://doi.wiley.com/10.1002/tdm_license_1.1
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Decision Making: physiology
|2 MeSH
650 _ 2 |a Drug Resistant Epilepsy: physiopathology
|2 MeSH
650 _ 2 |a Drug Resistant Epilepsy: psychology
|2 MeSH
650 _ 2 |a Drug Resistant Epilepsy: surgery
|2 MeSH
650 _ 2 |a Electrocorticography
|2 MeSH
650 _ 2 |a Epilepsy, Temporal Lobe: physiopathology
|2 MeSH
650 _ 2 |a Epilepsy, Temporal Lobe: psychology
|2 MeSH
650 _ 2 |a Epilepsy, Temporal Lobe: surgery
|2 MeSH
650 _ 2 |a Evoked Potentials
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Hippocampus: physiopathology
|2 MeSH
650 _ 2 |a Hippocampus: surgery
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Judgment: physiology
|2 MeSH
650 _ 2 |a Language Tests
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Memory: physiology
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Neuropsychological Tests
|2 MeSH
650 _ 2 |a Photic Stimulation
|2 MeSH
650 _ 2 |a Reaction Time
|2 MeSH
650 _ 2 |a Reading
|2 MeSH
650 _ 2 |a Semantics
|2 MeSH
650 _ 2 |a Visual Perception: physiology
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
700 1 _ |a Do Lam, A. T. A.
|b 1
700 1 _ |a Axmacher, N.
|0 P:(DE-2719)2000052
|b 2
|u dzne
700 1 _ |a Elger, C. E.
|b 3
700 1 _ |a Helmstaedter, C.
|b 4
700 1 _ |a Henke, K.
|b 5
700 1 _ |a Fell, J.
|b 6
773 1 8 |a 10.1002/hipo.22490
|b : Wiley, 2015-07-24
|n 1
|p 54-66
|3 journal-article
|2 Crossref
|t Hippocampus
|v 26
|y 2015
|x 1050-9631
773 _ _ |a 10.1002/hipo.22490
|g Vol. 26, no. 1, p. 54 - 66
|0 PERI:(DE-600)1498049-6
|n 1
|q 26:1<54 - 66
|p 54-66
|t Hippocampus
|v 26
|y 2015
|x 1050-9631
909 C O |o oai:pub.dzne.de:138364
|p VDB
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
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913 1 _ |a DE-HGF
|b Forschungsbereich Gesundheit
|l Erkrankungen des Nervensystems
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|0 G:(DE-HGF)POF3-344
|2 G:(DE-HGF)POF3-300
|v Clinical and Health Care Research
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914 1 _ |y 2016
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