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001     138369
005     20240321220424.0
024 7 _ |a 10.1038/npp.2015.245
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024 7 _ |a pmid:26272050
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024 7 _ |a pmc:PMC4748433
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024 7 _ |a 0893-133X
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024 7 _ |a 1740-634X
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037 _ _ |a DZNE-2020-04691
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Eckstein, Monika
|b 0
245 _ _ |a Oxytocin Facilitates Pavlovian Fear Learning in Males.
260 _ _ |a Basingstoke
|c 2016
|b Nature Publishing Group71819
264 _ 1 |3 online
|2 Crossref
|b Springer Science and Business Media LLC
|c 2015-08-14
264 _ 1 |3 print
|2 Crossref
|b Springer Science and Business Media LLC
|c 2016-03-01
336 7 _ |a article
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336 7 _ |a Journal Article
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520 _ _ |a In human evolution, social group living and Pavlovian fear conditioning have evolved as adaptive mechanisms promoting survival and reproductive success. The evolutionarily conserved hypothalamic peptide oxytocin is a key modulator of human sociality, but its effects on fear conditioning are still elusive. In the present randomized controlled study involving 97 healthy male subjects, we therefore employed functional magnetic resonance imaging and simultaneous skin conductance response (SCR) measures to characterize the modulatory influence of intranasal oxytocin (24 IU) on Pavlovian fear conditioning. We found that the peptide strengthened conditioning on both the behavioral and neural levels. Specifically, subjects exhibited faster task-related responses and enhanced SCRs to fear-associated stimuli in the late phase of conditioning, which was paralleled by heightened activity in cingulate cortex subregions in the absence of changes in amygdala function. This speaks against amygdalocentric views of oxytocin having pure anxiolytic-like effects. Instead, it suggests that the peptide enables extremely rapid and flexible adaptation to fear signals in social contexts, which may confer clear evolutionary advantages but could also elevate vulnerability for the pathological sequelae of interpersonal trauma.
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542 _ _ |i 2015-08-14
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650 _ 7 |a Oxytocin
|0 50-56-6
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650 _ 2 |a Administration, Intranasal
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Brain Mapping
|2 MeSH
650 _ 2 |a Conditioning, Classical: drug effects
|2 MeSH
650 _ 2 |a Conditioning, Classical: physiology
|2 MeSH
650 _ 2 |a Double-Blind Method
|2 MeSH
650 _ 2 |a Fear: drug effects
|2 MeSH
650 _ 2 |a Fear: physiology
|2 MeSH
650 _ 2 |a Galvanic Skin Response
|2 MeSH
650 _ 2 |a Gyrus Cinguli: drug effects
|2 MeSH
650 _ 2 |a Gyrus Cinguli: physiology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Oxytocin: administration & dosage
|2 MeSH
650 _ 2 |a Oxytocin: physiology
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
700 1 _ |a Scheele, Dirk
|b 1
700 1 _ |a Patin, Alexandra
|b 2
700 1 _ |a Preckel, Katrin
|b 3
700 1 _ |a Becker, Benjamin
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700 1 _ |a Walter, Annika
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700 1 _ |a Domschke, Katharina
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700 1 _ |a Grinevich, Valery
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700 1 _ |a Maier, Wolfgang
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700 1 _ |a Hurlemann, René
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773 1 8 |a 10.1038/npp.2015.245
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773 _ _ |a 10.1038/npp.2015.245
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856 7 _ |2 Pubmed Central
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856 4 _ |u https://pub.dzne.de/record/138369/files/DZNE-2020-04691_Restricted.pdf
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