000138377 001__ 138377
000138377 005__ 20240826163725.0
000138377 0247_ $$2doi$$a10.1093/brain/awv346
000138377 0247_ $$2pmid$$apmid:26647156
000138377 0247_ $$2pmc$$apmc:PMC4805087
000138377 0247_ $$2ISSN$$a0006-8950
000138377 0247_ $$2ISSN$$a1460-2156
000138377 0247_ $$2altmetric$$aaltmetric:4852819
000138377 037__ $$aDZNE-2020-04699
000138377 041__ $$aEnglish
000138377 082__ $$a610
000138377 1001_ $$0P:(DE-HGF)0$$aStuendl, Anne$$b0
000138377 245__ $$aInduction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies.
000138377 260__ $$aOxford$$bOxford Univ. Press$$c2016
000138377 264_1 $$2Crossref$$3online$$bOxford University Press (OUP)$$c2015-12-08
000138377 264_1 $$2Crossref$$3print$$bOxford University Press (OUP)$$c2016-02-01
000138377 3367_ $$2DRIVER$$aarticle
000138377 3367_ $$2DataCite$$aOutput Types/Journal article
000138377 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1724675667_21453
000138377 3367_ $$2BibTeX$$aARTICLE
000138377 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000138377 3367_ $$00$$2EndNote$$aJournal Article
000138377 520__ $$aExtracellular α-synuclein has been proposed as a crucial mechanism for induction of pathological aggregate formation in previously healthy cells. In vitro, extracellular α-synuclein is partially associated with exosomal vesicles. Recently, we have provided evidence that exosomal α-synuclein is present in the central nervous system in vivo. We hypothesized that exosomal α-synuclein species from patients with α-synuclein related neurodegeneration serve as carriers for interneuronal disease transmission. We isolated exosomes from cerebrospinal fluid from patients with Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy as a non-α-synuclein related disorder that clinically overlaps with Parkinson's disease, and neurological controls. Cerebrospinal fluid exosome numbers, α-synuclein protein content of cerebrospinal fluid exosomes and their potential to induce oligomerization of α-synuclein were analysed. The quantification of cerebrospinal fluid exosomal α-synuclein showed distinct differences between patients with Parkinson's disease and dementia with Lewy bodies. In addition, exosomal α-synuclein levels correlated with the severity of cognitive impairment in cross-sectional samples from patients with dementia with Lewy bodies. Importantly, cerebrospinal fluid exosomes derived from Parkinson's disease and dementia with Lewy bodies induce oligomerization of α-synuclein in a reporter cell line in a dose-dependent manner. Our data suggest that cerebrospinal fluid exosomes from patients with Parkinson's disease and dementia with Lewy bodies contain a pathogenic species of α-synuclein, which could initiate oligomerization of soluble α-synuclein in target cells and confer disease pathology.
000138377 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000138377 588__ $$aDataset connected to CrossRef, PubMed,
000138377 650_7 $$2NLM Chemicals$$aProtein Aggregates
000138377 650_7 $$2NLM Chemicals$$aalpha-Synuclein
000138377 650_2 $$2MeSH$$aCerebrospinal Fluid: metabolism
000138377 650_2 $$2MeSH$$aCohort Studies
000138377 650_2 $$2MeSH$$aCross-Sectional Studies
000138377 650_2 $$2MeSH$$aExosomes: metabolism
000138377 650_2 $$2MeSH$$aFemale
000138377 650_2 $$2MeSH$$aFollow-Up Studies
000138377 650_2 $$2MeSH$$aHumans
000138377 650_2 $$2MeSH$$aLewy Body Disease: cerebrospinal fluid
000138377 650_2 $$2MeSH$$aLewy Body Disease: metabolism
000138377 650_2 $$2MeSH$$aLongitudinal Studies
000138377 650_2 $$2MeSH$$aMale
000138377 650_2 $$2MeSH$$aParkinson Disease: cerebrospinal fluid
000138377 650_2 $$2MeSH$$aParkinson Disease: metabolism
000138377 650_2 $$2MeSH$$aProtein Aggregates: physiology
000138377 650_2 $$2MeSH$$aalpha-Synuclein: biosynthesis
000138377 650_2 $$2MeSH$$aalpha-Synuclein: cerebrospinal fluid
000138377 7001_ $$0P:(DE-HGF)0$$aKunadt, Marcel$$b1
000138377 7001_ $$0P:(DE-HGF)0$$aKruse, Niels$$b2
000138377 7001_ $$0P:(DE-HGF)0$$aBartels, Claudia$$b3
000138377 7001_ $$0P:(DE-HGF)0$$aMoebius, Wiebke$$b4
000138377 7001_ $$0P:(DE-2719)9001513$$aDanzer, Karin M$$b5$$udzne
000138377 7001_ $$0P:(DE-HGF)0$$aMollenhauer, Brit$$b6
000138377 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b7$$eLast author
000138377 77318 $$2Crossref$$3journal-article$$a10.1093/brain/awv346$$b : Oxford University Press (OUP), 2015-12-08$$n2$$p481-494$$tBrain$$v139$$x0006-8950$$y2015
000138377 773__ $$0PERI:(DE-600)1474117-9$$a10.1093/brain/awv346$$gVol. 139, no. Pt 2, p. 481 - 494$$n2$$p481-494$$q139:Pt 2<481 - 494$$tBrain$$v139$$x0006-8950$$y2016
000138377 8564_ $$uhttps://pub.dzne.de/record/138377/files/DZNE-2020-04699.pdf$$yOpenAccess
000138377 8564_ $$uhttps://pub.dzne.de/record/138377/files/DZNE-2020-04699.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000138377 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805087
000138377 909CO $$ooai:pub.dzne.de:138377$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000138377 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9001513$$aExternal Institute$$b5$$kExtern
000138377 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812035$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000138377 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000138377 9141_ $$y2016
000138377 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000138377 915__ $$0LIC:(DE-HGF)CCBYNC4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial CC BY-NC 4.0
000138377 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000138377 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000138377 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBRAIN : 2017
000138377 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bBRAIN : 2017
000138377 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000138377 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000138377 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000138377 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000138377 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000138377 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000138377 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000138377 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000138377 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000138377 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000138377 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000138377 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000138377 9201_ $$0I:(DE-2719)1440011$$kAG Schneider Göttingen$$lTranslational Dementia Research Göttingen$$x0
000138377 980__ $$ajournal
000138377 980__ $$aVDB
000138377 980__ $$aUNRESTRICTED
000138377 980__ $$aI:(DE-2719)1440011
000138377 9801_ $$aFullTexts
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.nbd.2011.01.029$$o10.1016/j.nbd.2011.01.029
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fphys.2012.00124$$o10.3389/fphys.2012.00124
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0197-4580(02)00065-9$$o10.1016/S0197-4580(02)00065-9
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00702-002-0808-2$$o10.1007/s00702-002-0808-2
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/1750-1326-7-42$$o10.1186/1750-1326-7-42
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1471-4159.2009.06324.x$$o10.1111/j.1471-4159.2009.06324.x
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1096/fj.10-164624$$o10.1096/fj.10-164624
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0903691106$$o10.1073/pnas.0903691106
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1096/fj.03-0098fje$$o10.1096/fj.03-0098fje
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1096/fj.03-1449com$$o10.1096/fj.03-1449com
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.addr.2012.08.008$$o10.1016/j.addr.2012.08.008
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pone.0022225$$o10.1371/journal.pone.0022225
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.5699-09.2010$$o10.1523/JNEUROSCI.5699-09.2010
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pbio.0050158$$o10.1371/journal.pbio.0050158
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.mcn.2005.12.003$$o10.1016/j.mcn.2005.12.003
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1242/jcs.074088$$o10.1242/jcs.074088
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fphys.2012.00119$$o10.3389/fphys.2012.00119
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pbio.1001604$$o10.1371/journal.pbio.1001604
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3109/00207454.2014.961454$$o10.3109/00207454.2014.961454
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/alzrt255$$o10.1186/alzrt255
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/brain/awq008$$o10.1093/brain/awq008
000138377 999C5 $$2Crossref$$oKang 2013$$y2013
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/npp.2008.161$$o10.1038/npp.2008.161
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.expneurol.2009.09.016$$o10.1016/j.expneurol.2009.09.016
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ymeth.2012.03.016$$o10.1016/j.ymeth.2012.03.016
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00401-015-1408-1$$o10.1007/s00401-015-1408-1
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrneurol.2013.275$$o10.1038/nrneurol.2013.275
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.0692-05.2005$$o10.1523/JNEUROSCI.0692-05.2005
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/978-1-61779-551-0_23$$o10.1007/978-1-61779-551-0_23
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nm1746$$o10.1038/nm1746
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/mds.23012$$o10.1002/mds.23012
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/01.wnl.0000256715.13907.d3$$o10.1212/01.wnl.0000256715.13907.d3
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/WNL.47.1.1$$o10.1212/WNL.47.1.1
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1227157$$o10.1126/science.1227157
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1084/jem.20112457$$o10.1084/jem.20112457
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ymeth.2003.10.010$$o10.1016/j.ymeth.2003.10.010
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/1750-1326-5-12$$o10.1186/1750-1326-5-12
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/01.wnl.0000187889.17253.b1$$o10.1212/01.wnl.0000187889.17253.b1
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1159/000083178$$o10.1159/000083178
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2217/bmm.10.90$$o10.2217/bmm.10.90
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S1474-4422(11)70014-X$$o10.1016/S1474-4422(11)70014-X
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1136/jnnp.2010.206391$$o10.1136/jnnp.2010.206391
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00702-012-0784-0$$o10.1007/s00702-012-0784-0
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/WNL.0b013e3182a6cbd5$$o10.1212/WNL.0b013e3182a6cbd5
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neulet.2012.11.004$$o10.1016/j.neulet.2012.11.004
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/mds.23287$$o10.1002/mds.23287
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neurobiolaging.2011.06.022$$o10.1016/j.neurobiolaging.2011.06.022
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1097/01.jnen.0000171652.40083.15$$o10.1097/01.jnen.0000171652.40083.15
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1097/WCO.0b013e32835a30f4$$o10.1097/WCO.0b013e32835a30f4
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.brainres.2008.11.055$$o10.1016/j.brainres.2008.11.055
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M110.148460$$o10.1074/jbc.M110.148460
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neulet.2008.11.015$$o10.1016/j.neulet.2008.11.015
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1113/jphysiol.2013.264069$$o10.1113/jphysiol.2013.264069
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pone.0001867$$o10.1371/journal.pone.0001867
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jns.2009.02.321$$o10.1016/j.jns.2009.02.321
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/mds.25945$$o10.1002/mds.25945
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3233/JAD-2010-100186$$o10.3233/JAD-2010-100186
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00441-012-1428-2$$o10.1007/s00441-012-1428-2
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00401-014-1314-y$$o10.1007/s00401-014-1314-y
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.colsurfb.2011.05.013$$o10.1016/j.colsurfb.2011.05.013
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.95.11.6469$$o10.1073/pnas.95.11.6469
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M110.134775$$o10.1074/jbc.M110.134775
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/gps.4274$$o10.1002/gps.4274
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/WNL.0b013e3181fd613b$$o10.1212/WNL.0b013e3181fd613b
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.bbrc.2006.08.024$$o10.1016/j.bbrc.2006.08.024
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/emmm.201201823$$o10.1002/emmm.201201823
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/jth.12602$$o10.1111/jth.12602
000138377 999C5 $$2Crossref$$oVidal 1997$$y1997
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2011.08.033$$o10.1016/j.neuron.2011.08.033
000138377 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/mt.2011.164$$o10.1038/mt.2011.164